DegronMD

Uniprot ID: Q8IWD4

Source protein: Coiled-coil domain-containing protein 117

Source gene: CCDC117

Class: LIG_APCC_ABBAyCdc20_2

Location: 249:255

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9788

ASA_SCORE: 95.5

COIL: 0.7734

CONS_SCORE: 0.7919

DSS_SCORE: 0.6066

HELIX: 0.1957

FCONS_SCORE: 1.165

RIG_SCORE: 0.7444

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P256S	TCGA-AG-3881	READ	TCGA	RTELFSE	LIG_APCC_ABBAyCdc20_2	0.3056
p.S262Y	TCGA-AG-A002	READ	TCGA	RTELFSE	LIG_APCC_ABBAyCdc20_2	0.1389
p.R249I	TCGA-AP-A056	UCEC	TCGA	RTELFSE	LIG_APCC_ABBAyCdc20_2	0.8102
p.S254L	SIDM00327	Hodgkin's Lymphoma	GDSC	RTELFSE	LIG_APCC_ABBAyCdc20_2	0.6556
p.S254L	ACH-000754	Lymphoma	CCLE	RTELFSE	LIG_APCC_ABBAyCdc20_2	0.6556
p.S254L	L-428	haematopoietic_and_lymphoid_tissue	COSMIC	RTELFSE	LIG_APCC_ABBAyCdc20_2	0.6556
p.R257Q	SIDM00116	Non-Small Cell Lung Carcinoma	GDSC	RTELFSE	LIG_APCC_ABBAyCdc20_2	0.2778
p.R257Q	ACH-000343	Lung Cancer	CCLE	RTELFSE	LIG_APCC_ABBAyCdc20_2	0.2778
p.R257Q	NCI-H522	lung	COSMIC	RTELFSE	LIG_APCC_ABBAyCdc20_2	0.2778
p.R239Q	NCI-H522	lung	COSMIC	RTELFSE	LIG_APCC_ABBAyCdc20_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IWD4	Coiled-coil domain-containing protein 117	LIG_APCC_ABBAyCdc20_2	249:255	RTELFSE	APC,CDC20,FZR1	0.9788	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons