DegronMD - Q8IWP9(CCDC28A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q152H	TCGA-05-4398	LUAD	TCGA	QRPKLKRVM	DEG_APCC_DBOX_1	137:145	Mutation rewiring degron network	0.1389
p.Q152H	DO25847	LUAD	ICGC	QRPKLKRVM	DEG_APCC_DBOX_1	137:145	Mutation rewiring degron network	0.1389
p.R138Q	TCGA-F5-6814	READ	TCGA	QRPKLKRVM	DEG_APCC_DBOX_1	137:145	Mutation altering degron motif	0.7329
p.R138Q	DO233748	GACA	ICGC	QRPKLKRVM	DEG_APCC_DBOX_1	137:145	Mutation altering degron motif	0.7329
p.R138Q	DO36556	READ	ICGC	QRPKLKRVM	DEG_APCC_DBOX_1	137:145	Mutation altering degron motif	0.7329
p.M145K	TCGA-ZF-AA4V	BLCA	TCGA	QRPKLKRVM	DEG_APCC_DBOX_1	137:145	Mutation altering degron motif	0.6951
p.M145K	DO219087	BLCA	ICGC	QRPKLKRVM	DEG_APCC_DBOX_1	137:145	Mutation altering degron motif	0.6951
p.S134A	DO233086	GACA	ICGC	QRPKLKRVM	DEG_APCC_DBOX_1	137:145	Mutation rewiring degron network	0.25
p.A131V	DO228948	LICA	ICGC	QRPKLKRVM	DEG_APCC_DBOX_1	137:145	Mutation rewiring degron network	0.1667

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons