DegronMD

Uniprot ID: Q8IWP9

Source protein: Coiled-coil domain-containing protein 28A

Source gene: CCDC28A

Class: DEG_APCC_DBOX_1

Location: 137:145

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9217

ASA_SCORE: 104.3556

COIL: 0.5151

CONS_SCORE: 0.4192

DSS_SCORE: 0.7539

HELIX: 0.4742

FCONS_SCORE: 0.985

RIG_SCORE: 0.6916

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q152H	TCGA-05-4398	LUAD	TCGA	QRPKLKRVM	DEG_APCC_DBOX_1	0.1389
p.Q152H	DO25847	LUAD	ICGC	QRPKLKRVM	DEG_APCC_DBOX_1	0.1389
p.R138Q	TCGA-F5-6814	READ	TCGA	QRPKLKRVM	DEG_APCC_DBOX_1	0.7329
p.R138Q	DO233748	GACA	ICGC	QRPKLKRVM	DEG_APCC_DBOX_1	0.7329
p.R138Q	DO36556	READ	ICGC	QRPKLKRVM	DEG_APCC_DBOX_1	0.7329
p.M145K	TCGA-ZF-AA4V	BLCA	TCGA	QRPKLKRVM	DEG_APCC_DBOX_1	0.6951
p.M145K	DO219087	BLCA	ICGC	QRPKLKRVM	DEG_APCC_DBOX_1	0.6951
p.S134A	DO233086	GACA	ICGC	QRPKLKRVM	DEG_APCC_DBOX_1	0.25
p.A131V	DO228948	LICA	ICGC	QRPKLKRVM	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IWP9	Coiled-coil domain-containing protein 28A	DEG_APCC_DBOX_1	137:145	QRPKLKRVM	APC,CDC20,FZR1	0.9217	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons