DegronMD - Q8IWX7(UNC45B)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G802V	TCGA-05-4396	LUAD	TCGA	DRLKLVVLL	DEG_APCC_DBOX_1	804:812	Mutation rewiring degron network	0.2778
p.G802V	DO23838	LUAD	ICGC	DRLKLVVLL	DEG_APCC_DBOX_1	804:812	Mutation rewiring degron network	0.2778
p.F798L	TCGA-CA-6717	COAD	TCGA	DRLKLVVLL	DEG_APCC_DBOX_1	804:812	Mutation rewiring degron network	0.1667
p.F798L	DO8264	COAD	ICGC	DRLKLVVLL	DEG_APCC_DBOX_1	804:812	Mutation rewiring degron network	0.1667
p.Q795H	TCGA-EO-A22R	UCEC	TCGA	DRLKLVVLL	DEG_APCC_DBOX_1	804:812	Mutation rewiring degron network	0.0833
p.Q795H	DO42713	UCEC	ICGC	DRLKLVVLL	DEG_APCC_DBOX_1	804:812	Mutation rewiring degron network	0.0833
p.E796K	DO48457	BLCA	ICGC	DRLKLVVLL	DEG_APCC_DBOX_1	804:812	Mutation rewiring degron network	0.1111
p.V794L	DO229041	LICA	ICGC	DRLKLVVLL	DEG_APCC_DBOX_1	804:812	Mutation rewiring degron network	0.0556
p.V794L	DO229008	LICA	ICGC	DRLKLVVLL	DEG_APCC_DBOX_1	804:812	Mutation rewiring degron network	0.0556
p.K819N	DO229045	LICA	ICGC	DRLKLVVLL	DEG_APCC_DBOX_1	804:812	Mutation substituting flanking lysine	0.25
p.L799F	DO33376	PACA	ICGC	DRLKLVVLL	DEG_APCC_DBOX_1	804:812	Mutation rewiring degron network	0.1944
p.V820M	SIDM00683	Prostate Carcinoma	GDSC	DRLKLVVLL	DEG_APCC_DBOX_1	804:812	Mutation rewiring degron network	0.1111
p.V820M	ACH-000977	lymph node	CCLE	DRLKLVVLL	DEG_APCC_DBOX_1	804:812	Mutation rewiring degron network	0.1111
p.V820M	LNCaP-Clone-FGC	prostate	COSMIC	DRLKLVVLL	DEG_APCC_DBOX_1	804:812	Mutation rewiring degron network	0.1111
p.G802R	SIDM00565	Oral Cavity Carcinoma	GDSC	DRLKLVVLL	DEG_APCC_DBOX_1	804:812	Mutation rewiring degron network	0.2778
p.G802R	SIDM00600	Thyroid Gland Carcinoma	GDSC	DRLKLVVLL	DEG_APCC_DBOX_1	804:812	Mutation rewiring degron network	0.2778
p.G802R	SIDM00323	B-Cell Non-Hodgkin's Lymphoma	GDSC	DRLKLVVLL	DEG_APCC_DBOX_1	804:812	Mutation rewiring degron network	0.2778
p.G802R	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	DRLKLVVLL	DEG_APCC_DBOX_1	804:812	Mutation rewiring degron network	0.2778
p.G802R	SIDM00592	Oral Cavity Carcinoma	GDSC	DRLKLVVLL	DEG_APCC_DBOX_1	804:812	Mutation rewiring degron network	0.2778
p.G802R	SIDM00364	B-Lymphoblastic Leukemia	GDSC	DRLKLVVLL	DEG_APCC_DBOX_1	804:812	Mutation rewiring degron network	0.2778
p.G802R	SIDM01045	Endometrial Carcinoma	GDSC	DRLKLVVLL	DEG_APCC_DBOX_1	804:812	Mutation rewiring degron network	0.2778
p.G802R	SIDM00618	Hepatocellular Carcinoma	GDSC	DRLKLVVLL	DEG_APCC_DBOX_1	804:812	Mutation rewiring degron network	0.2778
p.G802R	SIDM01377	Ovarian Carcinoma	GDSC	DRLKLVVLL	DEG_APCC_DBOX_1	804:812	Mutation rewiring degron network	0.2778
p.G802R	SIDM01391	Neuroblastoma	GDSC	DRLKLVVLL	DEG_APCC_DBOX_1	804:812	Mutation rewiring degron network	0.2778
p.V818M	LNCaP-Clone-FGC	prostate	COSMIC	DRLKLVVLL	DEG_APCC_DBOX_1	804:812	Mutation rewiring degron network	0.1667

Kaplan plot for UNC45B in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

UNC45B

UniProt ID: Q8IWX7

Entrez ID: 146862

Protein name: Protein unc-45 homolog B (Unc-45B) (SMUNC45)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for UNC45B in