DegronMD

Uniprot ID: Q8IWX7

Source protein: Protein unc-45 homolog B

Source gene: UNC45B

Class: DEG_APCC_DBOX_1

Location: 804:812

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6228

ASA_SCORE: 26.2556

COIL: 0.1178

CONS_SCORE: 0.501

DSS_SCORE: 0.0896

HELIX: 0.8191

FCONS_SCORE: 1.2936

RIG_SCORE: 0.9141

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G802V	TCGA-05-4396	LUAD	TCGA	DRLKLVVLL	DEG_APCC_DBOX_1	0.2778
p.G802V	DO23838	LUAD	ICGC	DRLKLVVLL	DEG_APCC_DBOX_1	0.2778
p.F798L	TCGA-CA-6717	COAD	TCGA	DRLKLVVLL	DEG_APCC_DBOX_1	0.1667
p.F798L	DO8264	COAD	ICGC	DRLKLVVLL	DEG_APCC_DBOX_1	0.1667
p.Q795H	TCGA-EO-A22R	UCEC	TCGA	DRLKLVVLL	DEG_APCC_DBOX_1	0.0833
p.Q795H	DO42713	UCEC	ICGC	DRLKLVVLL	DEG_APCC_DBOX_1	0.0833
p.E796K	DO48457	BLCA	ICGC	DRLKLVVLL	DEG_APCC_DBOX_1	0.1111
p.V794L	DO229041	LICA	ICGC	DRLKLVVLL	DEG_APCC_DBOX_1	0.0556
p.V794L	DO229008	LICA	ICGC	DRLKLVVLL	DEG_APCC_DBOX_1	0.0556
p.K819N	DO229045	LICA	ICGC	DRLKLVVLL	DEG_APCC_DBOX_1	0.25
p.L799F	DO33376	PACA	ICGC	DRLKLVVLL	DEG_APCC_DBOX_1	0.1944
p.V820M	SIDM00683	Prostate Carcinoma	GDSC	DRLKLVVLL	DEG_APCC_DBOX_1	0.1111
p.V820M	ACH-000977	lymph_node	CCLE	DRLKLVVLL	DEG_APCC_DBOX_1	0.1111
p.V820M	LNCaP-Clone-FGC	prostate	COSMIC	DRLKLVVLL	DEG_APCC_DBOX_1	0.1111
p.G802R	SIDM00565	Oral Cavity Carcinoma	GDSC	DRLKLVVLL	DEG_APCC_DBOX_1	0.2778
p.G802R	SIDM00600	Thyroid Gland Carcinoma	GDSC	DRLKLVVLL	DEG_APCC_DBOX_1	0.2778
p.G802R	SIDM00323	B-Cell Non-Hodgkin's Lymphoma	GDSC	DRLKLVVLL	DEG_APCC_DBOX_1	0.2778
p.G802R	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	DRLKLVVLL	DEG_APCC_DBOX_1	0.2778
p.G802R	SIDM00592	Oral Cavity Carcinoma	GDSC	DRLKLVVLL	DEG_APCC_DBOX_1	0.2778
p.G802R	SIDM00364	B-Lymphoblastic Leukemia	GDSC	DRLKLVVLL	DEG_APCC_DBOX_1	0.2778
p.G802R	SIDM01045	Endometrial Carcinoma	GDSC	DRLKLVVLL	DEG_APCC_DBOX_1	0.2778
p.G802R	SIDM00618	Hepatocellular Carcinoma	GDSC	DRLKLVVLL	DEG_APCC_DBOX_1	0.2778
p.G802R	SIDM01377	Ovarian Carcinoma	GDSC	DRLKLVVLL	DEG_APCC_DBOX_1	0.2778
p.G802R	SIDM01391	Neuroblastoma	GDSC	DRLKLVVLL	DEG_APCC_DBOX_1	0.2778
p.V818M	LNCaP-Clone-FGC	prostate	COSMIC	DRLKLVVLL	DEG_APCC_DBOX_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DRLKLVVLL

Degron related mutations and impact score

Drug responses associated with UNC45B mutations

All proteins holding degron of DRLKLVVLL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IWX7	Protein unc-45 homolog B	DEG_APCC_DBOX_1	804:812	DRLKLVVLL	APC,CDC20,FZR1	0.6228	More...