DegronMD - Q8IWY4(SCUBE1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K833R	TCGA-AA-3947	COAD	TCGA	KRRILIVVP	DEG_APCC_DBOX_1	833:841	Mutation altering degron motif	0.6126
p.K833R	DO8192	COAD	ICGC	KRRILIVVP	DEG_APCC_DBOX_1	833:841	Mutation altering degron motif	0.6126
p.A829T	TCGA-BR-7851	STAD	TCGA	KRRILIVVP	DEG_APCC_DBOX_1	833:841	Mutation rewiring degron network	0.2222
p.A829T	DO38711	STAD	ICGC	KRRILIVVP	DEG_APCC_DBOX_1	833:841	Mutation rewiring degron network	0.2222
p.E823K	TCGA-DK-A2I1	BLCA	TCGA	KRRILIVVP	DEG_APCC_DBOX_1	833:841	Mutation rewiring degron network	0.0556
p.E823K	DO444	BLCA	ICGC	KRRILIVVP	DEG_APCC_DBOX_1	833:841	Mutation rewiring degron network	0.0556
p.A829V	TCGA-L5-A4OW	ESCA	TCGA	KRRILIVVP	DEG_APCC_DBOX_1	833:841	Mutation rewiring degron network	0.2222
p.A829V	DO229078	PRAD	ICGC	KRRILIVVP	DEG_APCC_DBOX_1	833:841	Mutation rewiring degron network	0.2222
p.P830R	DO225096	BRCA	ICGC	KRRILIVVP	DEG_APCC_DBOX_1	833:841	Mutation rewiring degron network	0.25
p.I836N	DO233146	GACA	ICGC	KRRILIVVP	DEG_APCC_DBOX_1	833:841	Mutation altering degron motif	0.6169
p.P846S	DO233767	GACA	ICGC	KRRILIVVP	DEG_APCC_DBOX_1	833:841	Mutation rewiring degron network	0.1944
p.C824S	DO230918	LUSC	ICGC	KRRILIVVP	DEG_APCC_DBOX_1	833:841	Mutation rewiring degron network	0.0833
p.C824S	DO224546	LUSC	ICGC	KRRILIVVP	DEG_APCC_DBOX_1	833:841	Mutation rewiring degron network	0.0833
p.F844L	DO230990	LUSC	ICGC	KRRILIVVP	DEG_APCC_DBOX_1	833:841	Mutation rewiring degron network	0.25
p.E850K	DO231120	LUSC	ICGC	KRRILIVVP	DEG_APCC_DBOX_1	833:841	Mutation rewiring degron network	0.0833
p.V839M	SIDM00433	T-Lymphoblastic Leukemia	GDSC	KRRILIVVP	DEG_APCC_DBOX_1	833:841	Mutation altering degron motif	0.6097
p.V839M	ACH-000795	Leukemia	CCLE	KRRILIVVP	DEG_APCC_DBOX_1	833:841	Mutation altering degron motif	0.6097
p.V839M	MOLT-13	haematopoietic and lymphoid tissue	COSMIC	KRRILIVVP	DEG_APCC_DBOX_1	833:841	Mutation altering degron motif	0.6097
p.I828V	SIDM00763	Non-Small Cell Lung Carcinoma	GDSC	KRRILIVVP	DEG_APCC_DBOX_1	833:841	Mutation rewiring degron network	0.1944
p.I828V	SIDM00948	Burkitt's Lymphoma	GDSC	KRRILIVVP	DEG_APCC_DBOX_1	833:841	Mutation rewiring degron network	0.1944
p.I828V	NCI-H1915	lung	COSMIC	KRRILIVVP	DEG_APCC_DBOX_1	833:841	Mutation rewiring degron network	0.1944
p.I828V	DG-75	haematopoietic and lymphoid tissue	COSMIC	KRRILIVVP	DEG_APCC_DBOX_1	833:841	Mutation rewiring degron network	0.1944

Kaplan plot for SCUBE1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SCUBE1

UniProt ID: Q8IWY4

Entrez ID: 80274

Protein name: Signal peptide, CUB and EGF-like domain-containing protein 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SCUBE1 in