DegronMD

Uniprot ID: Q8IWY4

Source protein: Signal peptide, CUB and EGF-like domain-containing protein 1

Source gene: SCUBE1

Class: DEG_APCC_DBOX_1

Location: 833:841

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.54

ASA_SCORE: 50.9667

COIL: 0.3562

CONS_SCORE: 0.5929

DSS_SCORE: 0.0935

HELIX: 0.0174

FCONS_SCORE: 0.9587

RIG_SCORE: 0.8996

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K833R	TCGA-AA-3947	COAD	TCGA	KRRILIVVP	DEG_APCC_DBOX_1	0.6126
p.K833R	DO8192	COAD	ICGC	KRRILIVVP	DEG_APCC_DBOX_1	0.6126
p.A829T	TCGA-BR-7851	STAD	TCGA	KRRILIVVP	DEG_APCC_DBOX_1	0.2222
p.A829T	DO38711	STAD	ICGC	KRRILIVVP	DEG_APCC_DBOX_1	0.2222
p.E823K	TCGA-DK-A2I1	BLCA	TCGA	KRRILIVVP	DEG_APCC_DBOX_1	0.0556
p.E823K	DO444	BLCA	ICGC	KRRILIVVP	DEG_APCC_DBOX_1	0.0556
p.A829V	TCGA-L5-A4OW	ESCA	TCGA	KRRILIVVP	DEG_APCC_DBOX_1	0.2222
p.A829V	DO229078	PRAD	ICGC	KRRILIVVP	DEG_APCC_DBOX_1	0.2222
p.P830R	DO225096	BRCA	ICGC	KRRILIVVP	DEG_APCC_DBOX_1	0.25
p.I836N	DO233146	GACA	ICGC	KRRILIVVP	DEG_APCC_DBOX_1	0.6169
p.P846S	DO233767	GACA	ICGC	KRRILIVVP	DEG_APCC_DBOX_1	0.1944
p.C824S	DO230918	LUSC	ICGC	KRRILIVVP	DEG_APCC_DBOX_1	0.0833
p.C824S	DO224546	LUSC	ICGC	KRRILIVVP	DEG_APCC_DBOX_1	0.0833
p.F844L	DO230990	LUSC	ICGC	KRRILIVVP	DEG_APCC_DBOX_1	0.25
p.E850K	DO231120	LUSC	ICGC	KRRILIVVP	DEG_APCC_DBOX_1	0.0833
p.V839M	SIDM00433	T-Lymphoblastic Leukemia	GDSC	KRRILIVVP	DEG_APCC_DBOX_1	0.6097
p.V839M	ACH-000795	Leukemia	CCLE	KRRILIVVP	DEG_APCC_DBOX_1	0.6097
p.V839M	MOLT-13	haematopoietic_and_lymphoid_tissue	COSMIC	KRRILIVVP	DEG_APCC_DBOX_1	0.6097
p.I828V	SIDM00763	Non-Small Cell Lung Carcinoma	GDSC	KRRILIVVP	DEG_APCC_DBOX_1	0.1944
p.I828V	SIDM00948	Burkitt's Lymphoma	GDSC	KRRILIVVP	DEG_APCC_DBOX_1	0.1944
p.I828V	NCI-H1915	lung	COSMIC	KRRILIVVP	DEG_APCC_DBOX_1	0.1944
p.I828V	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	KRRILIVVP	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IWY4	Signal peptide, CUB and EGF-like domain-containing protein 1	DEG_APCC_DBOX_1	833:841	KRRILIVVP	APC,CDC20,FZR1	0.54	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons