DegronMD - Q8IWZ6(BBS7)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E361D	TCGA-06-5416	GBM	TCGA	LRNELEHLQ	DEG_APCC_DBOX_1	345:353	Mutation rewiring degron network	0.1111
p.E361D	DO10880	GBM	ICGC	LRNELEHLQ	DEG_APCC_DBOX_1	345:353	Mutation rewiring degron network	0.1111
p.E361D	SIDM00193	Colorectal Carcinoma	GDSC	LRNELEHLQ	DEG_APCC_DBOX_1	345:353	Mutation rewiring degron network	0.1111
p.E361D	ACH-000991	Colon/Colorectal Cancer	CCLE	LRNELEHLQ	DEG_APCC_DBOX_1	345:353	Mutation rewiring degron network	0.1111
p.E361D	SNU-81	large intestine	COSMIC	LRNELEHLQ	DEG_APCC_DBOX_1	345:353	Mutation rewiring degron network	0.1111
p.E348K	TCGA-A6-5662	COAD	TCGA	LRNELEHLQ	DEG_APCC_DBOX_1	345:353	Mutation altering degron motif	0.591
p.E348K	DO9410	COAD	ICGC	LRNELEHLQ	DEG_APCC_DBOX_1	345:353	Mutation altering degron motif	0.591
p.K355Q	TCGA-AA-3966	COAD	TCGA	LRNELEHLQ	DEG_APCC_DBOX_1	345:353	Mutation blocking ubiquitination signal	0.7222
p.K355Q	DO10068	COAD	ICGC	LRNELEHLQ	DEG_APCC_DBOX_1	345:353	Mutation blocking ubiquitination signal	0.7222
p.Y354F	TCGA-AA-3966	COAD	TCGA	LRNELEHLQ	DEG_APCC_DBOX_1	345:353	Mutation rewiring degron network	0.3056
p.Y354F	DO10068	COAD	ICGC	LRNELEHLQ	DEG_APCC_DBOX_1	345:353	Mutation rewiring degron network	0.3056
p.Q336H	TCGA-AA-A010	COAD	TCGA	LRNELEHLQ	DEG_APCC_DBOX_1	345:353	Mutation rewiring degron network	0.0833
p.Q358R	TCGA-AP-A1DK	UCEC	TCGA	LRNELEHLQ	DEG_APCC_DBOX_1	345:353	Mutation rewiring degron network	0.1944
p.Q358R	DO42033	UCEC	ICGC	LRNELEHLQ	DEG_APCC_DBOX_1	345:353	Mutation rewiring degron network	0.1944
p.S343F	TCGA-D3-A8GM	SKCM	TCGA	LRNELEHLQ	DEG_APCC_DBOX_1	345:353	Mutation rewiring degron network	0.2778
p.S343F	DO50288	SKCM	ICGC	LRNELEHLQ	DEG_APCC_DBOX_1	345:353	Mutation rewiring degron network	0.2778
p.R346W	TCGA-DF-A2KU	UCEC	TCGA	LRNELEHLQ	DEG_APCC_DBOX_1	345:353	Mutation altering degron motif	0.8634
p.R346W	DO223286	UCEC	ICGC	LRNELEHLQ	DEG_APCC_DBOX_1	345:353	Mutation altering degron motif	0.8634
p.R346W	SIDM02021	Esophageal Carcinoma	GDSC	LRNELEHLQ	DEG_APCC_DBOX_1	345:353	Mutation altering degron motif	0.8634
p.R346W	SIDM00534	Colorectal Carcinoma	GDSC	LRNELEHLQ	DEG_APCC_DBOX_1	345:353	Mutation altering degron motif	0.8634
p.R346W	HT-115	large intestine	COSMIC	LRNELEHLQ	DEG_APCC_DBOX_1	345:353	Mutation altering degron motif	0.8634
p.I342N	TCGA-DK-A6AW	BLCA	TCGA	LRNELEHLQ	DEG_APCC_DBOX_1	345:353	Mutation rewiring degron network	0.25
p.I342N	DO48566	BLCA	ICGC	LRNELEHLQ	DEG_APCC_DBOX_1	345:353	Mutation rewiring degron network	0.25
p.Q353K	TCGA-L5-A8NS	ESCA	TCGA	LRNELEHLQ	DEG_APCC_DBOX_1	345:353	Mutation altering degron motif	0.5833

Kaplan plot for BBS7 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BBS7

UniProt ID: Q8IWZ6

Entrez ID: 55212

Protein name: Bardet-Biedl syndrome 7 protein (BBS2-like protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for BBS7 in