DegronMD

Uniprot ID: Q8IWZ6

Source protein: Bardet-Biedl syndrome 7 protein

Source gene: BBS7

Class: DEG_APCC_DBOX_1

Location: 345:353

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9039

ASA_SCORE: 86.4556

COIL: 0.0298

CONS_SCORE: 0.6207

DSS_SCORE: 0.4163

HELIX: 0.9696

FCONS_SCORE: 1.3507

RIG_SCORE: 0.7704

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R346W	TCGA-DF-A2KU	UCEC	TCGA	LRNELEHLQ	DEG_APCC_DBOX_1	0.8634
p.R346W	DO223286	UCEC	ICGC	LRNELEHLQ	DEG_APCC_DBOX_1	0.8634
p.R346W	SIDM02021	Esophageal Carcinoma	GDSC	LRNELEHLQ	DEG_APCC_DBOX_1	0.8634
p.R346W	SIDM00534	Colorectal Carcinoma	GDSC	LRNELEHLQ	DEG_APCC_DBOX_1	0.8634
p.R346W	HT-115	large_intestine	COSMIC	LRNELEHLQ	DEG_APCC_DBOX_1	0.8634
p.K355Q	TCGA-AA-3966	COAD	TCGA	LRNELEHLQ	DEG_APCC_DBOX_1	0.7222
p.K355Q	DO10068	COAD	ICGC	LRNELEHLQ	DEG_APCC_DBOX_1	0.7222
p.E348K	TCGA-A6-5662	COAD	TCGA	LRNELEHLQ	DEG_APCC_DBOX_1	0.591
p.E348K	DO9410	COAD	ICGC	LRNELEHLQ	DEG_APCC_DBOX_1	0.591
p.Q353K	TCGA-L5-A8NS	ESCA	TCGA	LRNELEHLQ	DEG_APCC_DBOX_1	0.5833
p.Y354F	TCGA-AA-3966	COAD	TCGA	LRNELEHLQ	DEG_APCC_DBOX_1	0.3056
p.Y354F	DO10068	COAD	ICGC	LRNELEHLQ	DEG_APCC_DBOX_1	0.3056
p.S343F	TCGA-D3-A8GM	SKCM	TCGA	LRNELEHLQ	DEG_APCC_DBOX_1	0.2778
p.S343F	DO50288	SKCM	ICGC	LRNELEHLQ	DEG_APCC_DBOX_1	0.2778
p.I342N	TCGA-DK-A6AW	BLCA	TCGA	LRNELEHLQ	DEG_APCC_DBOX_1	0.25
p.I342N	DO48566	BLCA	ICGC	LRNELEHLQ	DEG_APCC_DBOX_1	0.25
p.Q358R	TCGA-AP-A1DK	UCEC	TCGA	LRNELEHLQ	DEG_APCC_DBOX_1	0.1944
p.Q358R	DO42033	UCEC	ICGC	LRNELEHLQ	DEG_APCC_DBOX_1	0.1944
p.E361D	TCGA-06-5416	GBM	TCGA	LRNELEHLQ	DEG_APCC_DBOX_1	0.1111
p.E361D	DO10880	GBM	ICGC	LRNELEHLQ	DEG_APCC_DBOX_1	0.1111
p.E361D	SIDM00193	Colorectal Carcinoma	GDSC	LRNELEHLQ	DEG_APCC_DBOX_1	0.1111
p.E361D	ACH-000991	Colon/Colorectal Cancer	CCLE	LRNELEHLQ	DEG_APCC_DBOX_1	0.1111
p.E361D	SNU-81	large_intestine	COSMIC	LRNELEHLQ	DEG_APCC_DBOX_1	0.1111
p.Q336H	TCGA-AA-A010	COAD	TCGA	LRNELEHLQ	DEG_APCC_DBOX_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IWZ6	Bardet-Biedl syndrome 7 protein	DEG_APCC_DBOX_1	345:353	LRNELEHLQ	APC,CDC20,FZR1	0.9039	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons