DegronMD - Q8IX29(FBXO16)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G247V	TCGA-44-4112	LUAD	TCGA	MTPDFS	DEG_SCF_FBW7_1	254:259	Mutation rewiring degron network	0.1389
p.G247V	DO26032	LUAD	ICGC	MTPDFS	DEG_SCF_FBW7_1	254:259	Mutation rewiring degron network	0.1389
p.K265N	TCGA-AX-A0J0	UCEC	TCGA	MTPDFS	DEG_SCF_FBW7_1	254:259	Mutation substituting flanking lysine	0.2778
p.K265N	DO41133	UCEC	ICGC	MTPDFS	DEG_SCF_FBW7_1	254:259	Mutation substituting flanking lysine	0.2778
p.R251T	TCGA-BT-A20W	BLCA	TCGA	MTPDFS	DEG_SCF_FBW7_1	254:259	Mutation rewiring degron network	0.25
p.R251T	DO657	BLCA	ICGC	MTPDFS	DEG_SCF_FBW7_1	254:259	Mutation rewiring degron network	0.25
p.G247E	TCGA-E2-A56Z	BRCA	TCGA	MTPDFS	DEG_SCF_FBW7_1	254:259	Mutation rewiring degron network	0.1389
p.G247E	DO44101	BRCA	ICGC	MTPDFS	DEG_SCF_FBW7_1	254:259	Mutation rewiring degron network	0.1389
p.M254I	DO227709	COCA	ICGC	MTPDFS	DEG_SCF_FBW7_1	254:259	Mutation altering degron motif	0.6507
p.M254I	DO229010	COCA	ICGC	MTPDFS	DEG_SCF_FBW7_1	254:259	Mutation altering degron motif	0.6507
p.M254I	DO229013	COCA	ICGC	MTPDFS	DEG_SCF_FBW7_1	254:259	Mutation altering degron motif	0.6507
p.M254I	DO229016	COCA	ICGC	MTPDFS	DEG_SCF_FBW7_1	254:259	Mutation altering degron motif	0.6507
p.M254I	DO229003	COCA	ICGC	MTPDFS	DEG_SCF_FBW7_1	254:259	Mutation altering degron motif	0.6507
p.M254I	DO229005	COCA	ICGC	MTPDFS	DEG_SCF_FBW7_1	254:259	Mutation altering degron motif	0.6507
p.M254I	DO230659	LAML	ICGC	MTPDFS	DEG_SCF_FBW7_1	254:259	Mutation altering degron motif	0.6507
p.M254I	DO231140	LAML	ICGC	MTPDFS	DEG_SCF_FBW7_1	254:259	Mutation altering degron motif	0.6507
p.M254I	DO229047	LICA	ICGC	MTPDFS	DEG_SCF_FBW7_1	254:259	Mutation altering degron motif	0.6507
p.M254I	DO230974	LUSC	ICGC	MTPDFS	DEG_SCF_FBW7_1	254:259	Mutation altering degron motif	0.6507
p.Q253K	DO228986	LICA	ICGC	MTPDFS	DEG_SCF_FBW7_1	254:259	Mutation rewiring degron network	0.3056
p.N252K	DO229045	LICA	ICGC	MTPDFS	DEG_SCF_FBW7_1	254:259	Mutation rewiring degron network	0.2778
p.K268T	SIDM01060	Melanoma	GDSC	MTPDFS	DEG_SCF_FBW7_1	254:259	Mutation substituting flanking lysine	0.1944
p.K268T	IGR-1	skin	COSMIC	MTPDFS	DEG_SCF_FBW7_1	254:259	Mutation substituting flanking lysine	0.1944
p.K256T	ACH-000882	Skin Cancer	CCLE	MTPDFS	DEG_SCF_FBW7_1	254:259	Mutation altering degron motif	0.7306
p.K256T	IGR-1	skin	COSMIC	MTPDFS	DEG_SCF_FBW7_1	254:259	Mutation altering degron motif	0.7306
p.S268A	ACH-000957	Colon/Colorectal Cancer	CCLE	MTPDFS	DEG_SCF_FBW7_1	254:259	Mutation substituting flanking lysine	0.1944
p.S268A	LS-180	large intestine	COSMIC	MTPDFS	DEG_SCF_FBW7_1	254:259	Mutation substituting flanking lysine	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FBXO16

UniProt ID: Q8IX29

Entrez ID: 157574

Protein name: F-box only protein 16

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FBXO16 in