DegronMD

Uniprot ID: Q8IX29

Source protein: F-box only protein 16

Source gene: FBXO16

Class: DEG_SCF_FBW7_1

Location: 254:259

E3 ligase: FBXW7

DEGRON score: 0.9762

ASA_SCORE: 83.2667

COIL: 0.7997

CONS_SCORE: 0.4137

DSS_SCORE: 0.8244

HELIX: 0.1717

FCONS_SCORE: 1.0427

RIG_SCORE: 0.6438

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G247V	TCGA-44-4112	LUAD	TCGA	MTPDFS	DEG_SCF_FBW7_1	0.1389
p.G247V	DO26032	LUAD	ICGC	MTPDFS	DEG_SCF_FBW7_1	0.1389
p.K265N	TCGA-AX-A0J0	UCEC	TCGA	MTPDFS	DEG_SCF_FBW7_1	0.2778
p.K265N	DO41133	UCEC	ICGC	MTPDFS	DEG_SCF_FBW7_1	0.2778
p.R251T	TCGA-BT-A20W	BLCA	TCGA	MTPDFS	DEG_SCF_FBW7_1	0.25
p.R251T	DO657	BLCA	ICGC	MTPDFS	DEG_SCF_FBW7_1	0.25
p.G247E	TCGA-E2-A56Z	BRCA	TCGA	MTPDFS	DEG_SCF_FBW7_1	0.1389
p.G247E	DO44101	BRCA	ICGC	MTPDFS	DEG_SCF_FBW7_1	0.1389
p.M254I	DO227709	COCA	ICGC	MTPDFS	DEG_SCF_FBW7_1	0.6507
p.M254I	DO229010	COCA	ICGC	MTPDFS	DEG_SCF_FBW7_1	0.6507
p.M254I	DO229013	COCA	ICGC	MTPDFS	DEG_SCF_FBW7_1	0.6507
p.M254I	DO229016	COCA	ICGC	MTPDFS	DEG_SCF_FBW7_1	0.6507
p.M254I	DO229003	COCA	ICGC	MTPDFS	DEG_SCF_FBW7_1	0.6507
p.M254I	DO229005	COCA	ICGC	MTPDFS	DEG_SCF_FBW7_1	0.6507
p.M254I	DO230659	LAML	ICGC	MTPDFS	DEG_SCF_FBW7_1	0.6507
p.M254I	DO231140	LAML	ICGC	MTPDFS	DEG_SCF_FBW7_1	0.6507
p.M254I	DO229047	LICA	ICGC	MTPDFS	DEG_SCF_FBW7_1	0.6507
p.M254I	DO230974	LUSC	ICGC	MTPDFS	DEG_SCF_FBW7_1	0.6507
p.Q253K	DO228986	LICA	ICGC	MTPDFS	DEG_SCF_FBW7_1	0.3056
p.N252K	DO229045	LICA	ICGC	MTPDFS	DEG_SCF_FBW7_1	0.2778
p.K268T	SIDM01060	Melanoma	GDSC	MTPDFS	DEG_SCF_FBW7_1	0.1944
p.K268T	IGR-1	skin	COSMIC	MTPDFS	DEG_SCF_FBW7_1	0.1944
p.K256T	ACH-000882	Skin Cancer	CCLE	MTPDFS	DEG_SCF_FBW7_1	0.7306
p.K256T	IGR-1	skin	COSMIC	MTPDFS	DEG_SCF_FBW7_1	0.7306
p.S268A	ACH-000957	Colon/Colorectal Cancer	CCLE	MTPDFS	DEG_SCF_FBW7_1	0.1944
p.S268A	LS-180	large_intestine	COSMIC	MTPDFS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IX29	F-box only protein 16	DEG_SCF_FBW7_1	254:259	MTPDFS	FBXW7	0.9762	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons