DegronMD - Q8IXH8(CDH26)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L527M	TCGA-21-1080	LUSC	TCGA	LEPFSD	LIG_APCC_ABBA_1	527:532	Mutation altering degron motif	0.5999
p.L527M	DO26502	LUSC	ICGC	LEPFSD	LIG_APCC_ABBA_1	527:532	Mutation altering degron motif	0.5999
p.P525L	TCGA-78-7148	LUAD	TCGA	LEPFSD	LIG_APCC_ABBA_1	527:532	Mutation rewiring degron network	0.2778
p.P525L	DO26112	LUAD	ICGC	LEPFSD	LIG_APCC_ABBA_1	527:532	Mutation rewiring degron network	0.2778
p.P529L	TCGA-AA-3672	COAD	TCGA	LEPFSD	LIG_APCC_ABBA_1	527:532	Mutation altering degron motif	0.6471
p.P529L	TCGA-FI-A2D0	UCEC	TCGA	LEPFSD	LIG_APCC_ABBA_1	527:532	Mutation altering degron motif	0.6471
p.P529L	TCGA-FR-A726	SKCM	TCGA	LEPFSD	LIG_APCC_ABBA_1	527:532	Mutation altering degron motif	0.6471
p.P529L	DO9010	COAD	ICGC	LEPFSD	LIG_APCC_ABBA_1	527:532	Mutation altering degron motif	0.6471
p.P529L	DO48665	SKCM	ICGC	LEPFSD	LIG_APCC_ABBA_1	527:532	Mutation altering degron motif	0.6471
p.P529L	DO43891	UCEC	ICGC	LEPFSD	LIG_APCC_ABBA_1	527:532	Mutation altering degron motif	0.6471
p.H519Y	TCGA-EE-A29E	SKCM	TCGA	LEPFSD	LIG_APCC_ABBA_1	527:532	Mutation rewiring degron network	0.1111
p.H519Y	DO37831	SKCM	ICGC	LEPFSD	LIG_APCC_ABBA_1	527:532	Mutation rewiring degron network	0.1111
p.D524N	TCGA-IB-7651	PAAD	TCGA	LEPFSD	LIG_APCC_ABBA_1	527:532	Mutation rewiring degron network	0.25
p.D524N	DO46657	PAAD	ICGC	LEPFSD	LIG_APCC_ABBA_1	527:532	Mutation rewiring degron network	0.25
p.D524A	TCGA-IB-7651	PAAD	TCGA	LEPFSD	LIG_APCC_ABBA_1	527:532	Mutation rewiring degron network	0.25
p.D524A	DO46657	PAAD	ICGC	LEPFSD	LIG_APCC_ABBA_1	527:532	Mutation rewiring degron network	0.25
p.P517T	DO230341	COCA	ICGC	LEPFSD	LIG_APCC_ABBA_1	527:532	Mutation rewiring degron network	0.0556
p.E523D	DO227987	COCA	ICGC	LEPFSD	LIG_APCC_ABBA_1	527:532	Mutation rewiring degron network	0.2222
p.E528K	DO234249	ESAD	ICGC	LEPFSD	LIG_APCC_ABBA_1	527:532	Mutation altering degron motif	0.591
p.T541I	SIDM00779	Colorectal Carcinoma	GDSC	LEPFSD	LIG_APCC_ABBA_1	527:532	Mutation rewiring degron network	0.0833
p.T541I	NCI-H716	large intestine	COSMIC	LEPFSD	LIG_APCC_ABBA_1	527:532	Mutation rewiring degron network	0.0833
p.P525S	SIDM01059	Melanoma	GDSC	LEPFSD	LIG_APCC_ABBA_1	527:532	Mutation rewiring degron network	0.2778
p.P525S	ACH-000915	Skin Cancer	CCLE	LEPFSD	LIG_APCC_ABBA_1	527:532	Mutation rewiring degron network	0.2778
p.P525S	IPC-298	skin	COSMIC	LEPFSD	LIG_APCC_ABBA_1	527:532	Mutation rewiring degron network	0.2778
p.E521K	ACH-001068	Lymphoma	CCLE	LEPFSD	LIG_APCC_ABBA_1	527:532	Mutation rewiring degron network	0.1667

Kaplan plot for CDH26 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDH26

UniProt ID: Q8IXH8

Entrez ID: 60437

Protein name: Cadherin-like protein 26 (Cadherin-like protein VR20)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDH26 in