DegronMD

Uniprot ID: Q8IXH8

Source protein: Cadherin-like protein 26

Source gene: CDH26

Class: LIG_APCC_ABBA_1

Location: 527:532

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9906

ASA_SCORE: 74.7833

COIL: 0.9348

CONS_SCORE: 0.5378

DSS_SCORE: 0.4788

HELIX: 0.0188

FCONS_SCORE: 0.8685

RIG_SCORE: 0.7458

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L527M	TCGA-21-1080	LUSC	TCGA	LEPFSD	LIG_APCC_ABBA_1	0.5999
p.L527M	DO26502	LUSC	ICGC	LEPFSD	LIG_APCC_ABBA_1	0.5999
p.P525L	TCGA-78-7148	LUAD	TCGA	LEPFSD	LIG_APCC_ABBA_1	0.2778
p.P525L	DO26112	LUAD	ICGC	LEPFSD	LIG_APCC_ABBA_1	0.2778
p.P529L	TCGA-AA-3672	COAD	TCGA	LEPFSD	LIG_APCC_ABBA_1	0.6471
p.P529L	TCGA-FI-A2D0	UCEC	TCGA	LEPFSD	LIG_APCC_ABBA_1	0.6471
p.P529L	TCGA-FR-A726	SKCM	TCGA	LEPFSD	LIG_APCC_ABBA_1	0.6471
p.P529L	DO9010	COAD	ICGC	LEPFSD	LIG_APCC_ABBA_1	0.6471
p.P529L	DO48665	SKCM	ICGC	LEPFSD	LIG_APCC_ABBA_1	0.6471
p.P529L	DO43891	UCEC	ICGC	LEPFSD	LIG_APCC_ABBA_1	0.6471
p.H519Y	TCGA-EE-A29E	SKCM	TCGA	LEPFSD	LIG_APCC_ABBA_1	0.1111
p.H519Y	DO37831	SKCM	ICGC	LEPFSD	LIG_APCC_ABBA_1	0.1111
p.D524N	TCGA-IB-7651	PAAD	TCGA	LEPFSD	LIG_APCC_ABBA_1	0.25
p.D524N	DO46657	PAAD	ICGC	LEPFSD	LIG_APCC_ABBA_1	0.25
p.D524A	TCGA-IB-7651	PAAD	TCGA	LEPFSD	LIG_APCC_ABBA_1	0.25
p.D524A	DO46657	PAAD	ICGC	LEPFSD	LIG_APCC_ABBA_1	0.25
p.P517T	DO230341	COCA	ICGC	LEPFSD	LIG_APCC_ABBA_1	0.0556
p.E523D	DO227987	COCA	ICGC	LEPFSD	LIG_APCC_ABBA_1	0.2222
p.E528K	DO234249	ESAD	ICGC	LEPFSD	LIG_APCC_ABBA_1	0.591
p.T541I	SIDM00779	Colorectal Carcinoma	GDSC	LEPFSD	LIG_APCC_ABBA_1	0.0833
p.T541I	NCI-H716	large_intestine	COSMIC	LEPFSD	LIG_APCC_ABBA_1	0.0833
p.P525S	SIDM01059	Melanoma	GDSC	LEPFSD	LIG_APCC_ABBA_1	0.2778
p.P525S	ACH-000915	Skin Cancer	CCLE	LEPFSD	LIG_APCC_ABBA_1	0.2778
p.P525S	IPC-298	skin	COSMIC	LEPFSD	LIG_APCC_ABBA_1	0.2778
p.E521K	ACH-001068	Lymphoma	CCLE	LEPFSD	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IXH8	Cadherin-like protein 26	LIG_APCC_ABBA_1	527:532	LEPFSD	APC,CDC20,FZR1	0.9906	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons