DegronMD - Q8IXL7(MSRB3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G178D	TCGA-4Z-AA89	BLCA	TCGA	LSFTPADS	DEG_SCF_FBW7_1	164:171	Mutation rewiring degron network	0.1389
p.G178D	TCGA-PK-A5HB	ACC	TCGA	LSFTPADS	DEG_SCF_FBW7_1	164:171	Mutation rewiring degron network	0.1389
p.G178D	DO218991	BLCA	ICGC	LSFTPADS	DEG_SCF_FBW7_1	164:171	Mutation rewiring degron network	0.1389
p.P168A	TCGA-56-A62T	LUSC	TCGA	LSFTPADS	DEG_SCF_FBW7_1	164:171	Mutation altering degron motif	0.7503
p.P168A	DO219144	LUSC	ICGC	LSFTPADS	DEG_SCF_FBW7_1	164:171	Mutation altering degron motif	0.7503
p.S161L	TCGA-A6-2675	COAD	TCGA	LSFTPADS	DEG_SCF_FBW7_1	164:171	Mutation rewiring degron network	0.25
p.S161L	TCGA-AA-A00N	COAD	TCGA	LSFTPADS	DEG_SCF_FBW7_1	164:171	Mutation rewiring degron network	0.25
p.S161L	TCGA-BR-8680	STAD	TCGA	LSFTPADS	DEG_SCF_FBW7_1	164:171	Mutation rewiring degron network	0.25
p.S161L	TCGA-HZ-A4BH	PAAD	TCGA	LSFTPADS	DEG_SCF_FBW7_1	164:171	Mutation rewiring degron network	0.25
p.S161L	DO9876	COAD	ICGC	LSFTPADS	DEG_SCF_FBW7_1	164:171	Mutation rewiring degron network	0.25
p.S161L	DO8594	COAD	ICGC	LSFTPADS	DEG_SCF_FBW7_1	164:171	Mutation rewiring degron network	0.25
p.S161L	DO32814	PAAD	ICGC	LSFTPADS	DEG_SCF_FBW7_1	164:171	Mutation rewiring degron network	0.25
p.S161L	DO47769	STAD	ICGC	LSFTPADS	DEG_SCF_FBW7_1	164:171	Mutation rewiring degron network	0.25
p.S161L	SIDM01611	Endometrial Carcinoma	GDSC	LSFTPADS	DEG_SCF_FBW7_1	164:171	Mutation rewiring degron network	0.25
p.R156I	TCGA-B5-A0JY	UCEC	TCGA	LSFTPADS	DEG_SCF_FBW7_1	164:171	Mutation rewiring degron network	0.1111
p.R156I	DO43041	UCEC	ICGC	LSFTPADS	DEG_SCF_FBW7_1	164:171	Mutation rewiring degron network	0.1111
p.R156G	TCGA-CA-6717	COAD	TCGA	LSFTPADS	DEG_SCF_FBW7_1	164:171	Mutation rewiring degron network	0.1111
p.R156G	DO8264	COAD	ICGC	LSFTPADS	DEG_SCF_FBW7_1	164:171	Mutation rewiring degron network	0.1111
p.A175T	TCGA-CM-6168	COAD	TCGA	LSFTPADS	DEG_SCF_FBW7_1	164:171	Mutation rewiring degron network	0.2222
p.A175T	TCGA-EY-A215	UCEC	TCGA	LSFTPADS	DEG_SCF_FBW7_1	164:171	Mutation rewiring degron network	0.2222
p.A175T	DO9602	COAD	ICGC	LSFTPADS	DEG_SCF_FBW7_1	164:171	Mutation rewiring degron network	0.2222
p.A175T	DO42665	UCEC	ICGC	LSFTPADS	DEG_SCF_FBW7_1	164:171	Mutation rewiring degron network	0.2222
p.T174I	TCGA-D3-A5GO	SKCM	TCGA	LSFTPADS	DEG_SCF_FBW7_1	164:171	Mutation rewiring degron network	0.25
p.T174I	DO47419	SKCM	ICGC	LSFTPADS	DEG_SCF_FBW7_1	164:171	Mutation rewiring degron network	0.25
p.E176K	TCGA-FU-A3NI	CESC	TCGA	LSFTPADS	DEG_SCF_FBW7_1	164:171	Mutation rewiring degron network	0.1944
p.E176K	DO6293	CESC	ICGC	LSFTPADS	DEG_SCF_FBW7_1	164:171	Mutation rewiring degron network	0.1944
p.R156K	TCGA-W3-AA1R	SKCM	TCGA	LSFTPADS	DEG_SCF_FBW7_1	164:171	Mutation rewiring degron network	0.1111
p.R156K	DO51275	SKCM	ICGC	LSFTPADS	DEG_SCF_FBW7_1	164:171	Mutation rewiring degron network	0.1111
p.R156S	DO18164	KIRC	ICGC	LSFTPADS	DEG_SCF_FBW7_1	164:171	Mutation rewiring degron network	0.1111
p.S171C	DO25104	LUAD	ICGC	LSFTPADS	DEG_SCF_FBW7_1	164:171	Mutation altering degron motif	0.7541
p.G173A	DO46342	OV	ICGC	LSFTPADS	DEG_SCF_FBW7_1	164:171	Mutation rewiring degron network	0.2778
p.G154S	DO32843	PACA	ICGC	LSFTPADS	DEG_SCF_FBW7_1	164:171	Mutation rewiring degron network	0.0556
p.G154R	DO218850	SKCA	ICGC	LSFTPADS	DEG_SCF_FBW7_1	164:171	Mutation rewiring degron network	0.0556
p.G154E	DO218850	SKCA	ICGC	LSFTPADS	DEG_SCF_FBW7_1	164:171	Mutation rewiring degron network	0.0556
p.Y172C	SIDM00345	Non-Small Cell Lung Carcinoma	GDSC	LSFTPADS	DEG_SCF_FBW7_1	164:171	Mutation rewiring degron network	0.3056
p.A175D	ACH-000861	Lung Cancer	CCLE	LSFTPADS	DEG_SCF_FBW7_1	164:171	Mutation rewiring degron network	0.2222
p.A175D	HOP-62	lung	COSMIC	LSFTPADS	DEG_SCF_FBW7_1	164:171	Mutation rewiring degron network	0.2222
p.S154L	ACH-000996	Endometrial/Uterine Cancer	CCLE	LSFTPADS	DEG_SCF_FBW7_1	164:171	Mutation rewiring degron network	0.0556

Kaplan plot for MSRB3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MSRB3

UniProt ID: Q8IXL7

Entrez ID: 253827

Protein name: Methionine-R-sulfoxide reductase B3 (MsrB3) (EC 1.8.4.12) (EC 1.8.4.14)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MSRB3 in