DegronMD

Uniprot ID: Q8IXL7

Source protein: Methionine-R-sulfoxide reductase B3

Source gene: MSRB3

Class: DEG_SCF_FBW7_1

Location: 164:171

E3 ligase: FBXW7

DEGRON score: 0.5767

ASA_SCORE: 57.525

COIL: 0.3969

CONS_SCORE: 0.5557

DSS_SCORE: 0.3762

HELIX: 0.0236

FCONS_SCORE: 0.9925

RIG_SCORE: 0.704

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G178D	TCGA-4Z-AA89	BLCA	TCGA	LSFTPADS	DEG_SCF_FBW7_1	0.1389
p.G178D	TCGA-PK-A5HB	ACC	TCGA	LSFTPADS	DEG_SCF_FBW7_1	0.1389
p.G178D	DO218991	BLCA	ICGC	LSFTPADS	DEG_SCF_FBW7_1	0.1389
p.P168A	TCGA-56-A62T	LUSC	TCGA	LSFTPADS	DEG_SCF_FBW7_1	0.7503
p.P168A	DO219144	LUSC	ICGC	LSFTPADS	DEG_SCF_FBW7_1	0.7503
p.S161L	TCGA-A6-2675	COAD	TCGA	LSFTPADS	DEG_SCF_FBW7_1	0.25
p.S161L	TCGA-AA-A00N	COAD	TCGA	LSFTPADS	DEG_SCF_FBW7_1	0.25
p.S161L	TCGA-BR-8680	STAD	TCGA	LSFTPADS	DEG_SCF_FBW7_1	0.25
p.S161L	TCGA-HZ-A4BH	PAAD	TCGA	LSFTPADS	DEG_SCF_FBW7_1	0.25
p.S161L	DO9876	COAD	ICGC	LSFTPADS	DEG_SCF_FBW7_1	0.25
p.S161L	DO8594	COAD	ICGC	LSFTPADS	DEG_SCF_FBW7_1	0.25
p.S161L	DO32814	PAAD	ICGC	LSFTPADS	DEG_SCF_FBW7_1	0.25
p.S161L	DO47769	STAD	ICGC	LSFTPADS	DEG_SCF_FBW7_1	0.25
p.S161L	SIDM01611	Endometrial Carcinoma	GDSC	LSFTPADS	DEG_SCF_FBW7_1	0.25
p.R156I	TCGA-B5-A0JY	UCEC	TCGA	LSFTPADS	DEG_SCF_FBW7_1	0.1111
p.R156I	DO43041	UCEC	ICGC	LSFTPADS	DEG_SCF_FBW7_1	0.1111
p.R156G	TCGA-CA-6717	COAD	TCGA	LSFTPADS	DEG_SCF_FBW7_1	0.1111
p.R156G	DO8264	COAD	ICGC	LSFTPADS	DEG_SCF_FBW7_1	0.1111
p.A175T	TCGA-CM-6168	COAD	TCGA	LSFTPADS	DEG_SCF_FBW7_1	0.2222
p.A175T	TCGA-EY-A215	UCEC	TCGA	LSFTPADS	DEG_SCF_FBW7_1	0.2222
p.A175T	DO9602	COAD	ICGC	LSFTPADS	DEG_SCF_FBW7_1	0.2222
p.A175T	DO42665	UCEC	ICGC	LSFTPADS	DEG_SCF_FBW7_1	0.2222
p.T174I	TCGA-D3-A5GO	SKCM	TCGA	LSFTPADS	DEG_SCF_FBW7_1	0.25
p.T174I	DO47419	SKCM	ICGC	LSFTPADS	DEG_SCF_FBW7_1	0.25
p.E176K	TCGA-FU-A3NI	CESC	TCGA	LSFTPADS	DEG_SCF_FBW7_1	0.1944
p.E176K	DO6293	CESC	ICGC	LSFTPADS	DEG_SCF_FBW7_1	0.1944
p.R156K	TCGA-W3-AA1R	SKCM	TCGA	LSFTPADS	DEG_SCF_FBW7_1	0.1111
p.R156K	DO51275	SKCM	ICGC	LSFTPADS	DEG_SCF_FBW7_1	0.1111
p.R156S	DO18164	KIRC	ICGC	LSFTPADS	DEG_SCF_FBW7_1	0.1111
p.S171C	DO25104	LUAD	ICGC	LSFTPADS	DEG_SCF_FBW7_1	0.7541
p.G173A	DO46342	OV	ICGC	LSFTPADS	DEG_SCF_FBW7_1	0.2778
p.G154S	DO32843	PACA	ICGC	LSFTPADS	DEG_SCF_FBW7_1	0.0556
p.G154R	DO218850	SKCA	ICGC	LSFTPADS	DEG_SCF_FBW7_1	0.0556
p.G154E	DO218850	SKCA	ICGC	LSFTPADS	DEG_SCF_FBW7_1	0.0556
p.Y172C	SIDM00345	Non-Small Cell Lung Carcinoma	GDSC	LSFTPADS	DEG_SCF_FBW7_1	0.3056
p.A175D	ACH-000861	Lung Cancer	CCLE	LSFTPADS	DEG_SCF_FBW7_1	0.2222
p.A175D	HOP-62	lung	COSMIC	LSFTPADS	DEG_SCF_FBW7_1	0.2222
p.S154L	ACH-000996	Endometrial/Uterine Cancer	CCLE	LSFTPADS	DEG_SCF_FBW7_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LSFTPADS

Degron related mutations and impact score

Drug responses associated with MSRB3 mutations

All proteins holding degron of LSFTPADS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IXL7	Methionine-R-sulfoxide reductase B3	DEG_SCF_FBW7_1	164:171	LSFTPADS	FBXW7	0.5767	More...