MRPL41
UniProt ID: Q8IXM3
Entrez ID: 64975
Protein name: 39S ribosomal protein L41, mitochondrial (L41mt) (MRP-L41) (39S ribosomal protein L27 homolog) (Bcl-2-interacting mitochondrial ribosomal protein L41) (Cell proliferation-inducing gene 3 protein) (MRP-L27 homolog) (Mitochondrial large ribosomal subunit protein mL41)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Component of the mitochondrial ribosome large subunit (PubMed:28892042, PubMed:25838379, PubMed:25278503). Also involved in apoptosis and cell cycle (PubMed:16024796, PubMed:16256947). Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inh...
FUNCTION: Component of the mitochondrial ribosome large subunit (PubMed:28892042, PubMed:25838379, PubMed:25278503). Also involved in apoptosis and cell cycle (PubMed:16024796, PubMed:16256947). Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins (PubMed:16024796). {ECO:0000269|PubMed:16024796, ECO:0000269|PubMed:16256947, ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
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GO - Biological processes (BP):
apoptotic process [GO:0006915]; cell cycle [GO:0007049]; mitochondrial translation [GO:0032543]; translation [GO:0006412]...
apoptotic process [GO:0006915]; cell cycle [GO:0007049]; mitochondrial translation [GO:0032543]; translation [GO:0006412]
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GO - Molecular function (MF):
RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]...
RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]
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GO - Cellular component (CC):
mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; ribonucleoprotein complex [GO:1990904]...
mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; ribonucleoprotein complex [GO:1990904]
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MRPL41
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Kaplan plot for MRPL41 in
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*NOTE: the Kaplan plots were collected from OncoLnc