DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
FLR
Uniprot ID:
Q8IXM3
Source protein:
39S ribosomal protein L41, mitochondrial
Source gene:
MRPL41
Class:
DEG_APCC_TPR_1
Location:
135:137
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8894
ASA_SCORE:
120.2
COIL:
0.8387
CONS_SCORE:
0.3771
DSS_SCORE:
0.7445
HELIX:
0.1453
FCONS_SCORE:
0.8163
RIG_SCORE:
0.8236
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P132T
TCGA-FS-A1Z4
SKCM
TCGA
FLR
DEG_APCC_TPR_1
0.25
p.P132T
DO37462
SKCM
ICGC
FLR
DEG_APCC_TPR_1
0.25
Drug responses associated with MRPL41 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of FLR
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8IXM3
39S ribosomal protein L41, mitochondrial
DEG_APCC_TPR_1
135:137
FLR
APC,CDC20,FZR1
0.8894
More...