DegronMD - Q8IXR9(C12orf56)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S184Y	TCGA-AN-A046	BRCA	TCGA	PRPGLKKLS	DEG_APCC_DBOX_1	179:187	Mutation altering degron motif	0.712
p.S184Y	TCGA-FI-A2D5	UCEC	TCGA	PRPGLKKLS	DEG_APCC_DBOX_1	179:187	Mutation altering degron motif	0.712
p.S190Y	TCGA-AP-A056	UCEC	TCGA	PRPGLKKLS	DEG_APCC_DBOX_1	179:187	Mutation rewiring degron network	0.25
p.K196T	TCGA-VS-A8QH	CESC	TCGA	PRPGLKKLS	DEG_APCC_DBOX_1	179:187	Mutation rewiring degron network	0.0833
p.Q191K	DO228948	LICA	ICGC	PRPGLKKLS	DEG_APCC_DBOX_1	179:187	Mutation rewiring degron network	0.2222
p.R180C	DO220880	MELA	ICGC	PRPGLKKLS	DEG_APCC_DBOX_1	179:187	Mutation altering degron motif	0.8301
p.G190S	DO220902	MELA	ICGC	PRPGLKKLS	DEG_APCC_DBOX_1	179:187	Mutation rewiring degron network	0.25
p.G190S	DO47255	SKCM	ICGC	PRPGLKKLS	DEG_APCC_DBOX_1	179:187	Mutation rewiring degron network	0.25
p.G192V	SIDM00068	Colorectal Carcinoma	GDSC	PRPGLKKLS	DEG_APCC_DBOX_1	179:187	Mutation rewiring degron network	0.1944

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons