DegronMD

Uniprot ID: Q8IXR9

Source protein: Uncharacterized protein C12orf56

Source gene: C12orf56

Class: DEG_APCC_DBOX_1

Location: 179:187

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8776

ASA_SCORE: 83.9333

COIL: 0.7804

CONS_SCORE: 0.4171

DSS_SCORE: 0.6622

HELIX: 0.1218

FCONS_SCORE: 1.0646

RIG_SCORE: 0.6637

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S184Y	TCGA-AN-A046	BRCA	TCGA	PRPGLKKLS	DEG_APCC_DBOX_1	0.712
p.S184Y	TCGA-FI-A2D5	UCEC	TCGA	PRPGLKKLS	DEG_APCC_DBOX_1	0.712
p.S190Y	TCGA-AP-A056	UCEC	TCGA	PRPGLKKLS	DEG_APCC_DBOX_1	0.25
p.K196T	TCGA-VS-A8QH	CESC	TCGA	PRPGLKKLS	DEG_APCC_DBOX_1	0.0833
p.Q191K	DO228948	LICA	ICGC	PRPGLKKLS	DEG_APCC_DBOX_1	0.2222
p.R180C	DO220880	MELA	ICGC	PRPGLKKLS	DEG_APCC_DBOX_1	0.8301
p.G190S	DO220902	MELA	ICGC	PRPGLKKLS	DEG_APCC_DBOX_1	0.25
p.G190S	DO47255	SKCM	ICGC	PRPGLKKLS	DEG_APCC_DBOX_1	0.25
p.G192V	SIDM00068	Colorectal Carcinoma	GDSC	PRPGLKKLS	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IXR9	Uncharacterized protein C12orf56	DEG_APCC_DBOX_1	179:187	PRPGLKKLS	APC,CDC20,FZR1	0.8776	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons