DegronMD - Q8IXS0(FAM217A)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P249H	TCGA-AD-6889	COAD	TCGA	VFPYPD	LIG_APCC_ABBA_1	245:250	Mutation altering degron motif	0.6583
p.P249H	DO8463	COAD	ICGC	VFPYPD	LIG_APCC_ABBA_1	245:250	Mutation altering degron motif	0.6583
p.E236K	TCGA-EE-A2MR	SKCM	TCGA	VFPYPD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.0833
p.E236K	TCGA-FW-A3R5	SKCM	TCGA	VFPYPD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.0833
p.E236K	DO37819	SKCM	ICGC	VFPYPD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.0833
p.E236K	DO37406	SKCM	ICGC	VFPYPD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.0833
p.A258T	DO229010	COCA	ICGC	VFPYPD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.1111
p.A258T	DO229013	COCA	ICGC	VFPYPD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.1111
p.A258T	DO229016	COCA	ICGC	VFPYPD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.1111
p.A258T	DO230659	LAML	ICGC	VFPYPD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.1111
p.A258T	DO231140	LAML	ICGC	VFPYPD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.1111
p.A258T	DO228941	LICA	ICGC	VFPYPD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.1111
p.A258T	DO229047	LICA	ICGC	VFPYPD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.1111
p.P249T	DO229018	LICA	ICGC	VFPYPD	LIG_APCC_ABBA_1	245:250	Mutation altering degron motif	0.5919
p.F238L	DO229006	LICA	ICGC	VFPYPD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.1389
p.E240Q	SIDM00061	Ovarian Carcinoma	GDSC	VFPYPD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.1944
p.E240Q	SIDM00134	Non-Small Cell Lung Carcinoma	GDSC	VFPYPD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.1944
p.E240Q	SIDM00925	Non-Small Cell Lung Carcinoma	GDSC	VFPYPD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.1944
p.L259P	SIDM00789	Colorectal Carcinoma	GDSC	VFPYPD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.0833
p.L259P	ACH-000997	Colon/Colorectal Cancer	CCLE	VFPYPD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.0833
p.L259P	HCT-15	large intestine	COSMIC	VFPYPD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAM217A

UniProt ID: Q8IXS0

Entrez ID: 222826

Protein name: Protein FAM217A

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAM217A in