DegronMD

Uniprot ID: Q8IXS0

Source protein: Protein FAM217A

Source gene: FAM217A

Class: LIG_APCC_ABBA_1

Location: 245:250

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9937

ASA_SCORE: 59.5667

COIL: 0.8187

CONS_SCORE: 0.6032

DSS_SCORE: 0.4581

HELIX: 0.0713

FCONS_SCORE: 0.885

RIG_SCORE: 0.7796

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P249H	TCGA-AD-6889	COAD	TCGA	VFPYPD	LIG_APCC_ABBA_1	0.6583
p.P249H	DO8463	COAD	ICGC	VFPYPD	LIG_APCC_ABBA_1	0.6583
p.E236K	TCGA-EE-A2MR	SKCM	TCGA	VFPYPD	LIG_APCC_ABBA_1	0.0833
p.E236K	TCGA-FW-A3R5	SKCM	TCGA	VFPYPD	LIG_APCC_ABBA_1	0.0833
p.E236K	DO37819	SKCM	ICGC	VFPYPD	LIG_APCC_ABBA_1	0.0833
p.E236K	DO37406	SKCM	ICGC	VFPYPD	LIG_APCC_ABBA_1	0.0833
p.A258T	DO229010	COCA	ICGC	VFPYPD	LIG_APCC_ABBA_1	0.1111
p.A258T	DO229013	COCA	ICGC	VFPYPD	LIG_APCC_ABBA_1	0.1111
p.A258T	DO229016	COCA	ICGC	VFPYPD	LIG_APCC_ABBA_1	0.1111
p.A258T	DO230659	LAML	ICGC	VFPYPD	LIG_APCC_ABBA_1	0.1111
p.A258T	DO231140	LAML	ICGC	VFPYPD	LIG_APCC_ABBA_1	0.1111
p.A258T	DO228941	LICA	ICGC	VFPYPD	LIG_APCC_ABBA_1	0.1111
p.A258T	DO229047	LICA	ICGC	VFPYPD	LIG_APCC_ABBA_1	0.1111
p.P249T	DO229018	LICA	ICGC	VFPYPD	LIG_APCC_ABBA_1	0.5919
p.F238L	DO229006	LICA	ICGC	VFPYPD	LIG_APCC_ABBA_1	0.1389
p.E240Q	SIDM00061	Ovarian Carcinoma	GDSC	VFPYPD	LIG_APCC_ABBA_1	0.1944
p.E240Q	SIDM00134	Non-Small Cell Lung Carcinoma	GDSC	VFPYPD	LIG_APCC_ABBA_1	0.1944
p.E240Q	SIDM00925	Non-Small Cell Lung Carcinoma	GDSC	VFPYPD	LIG_APCC_ABBA_1	0.1944
p.L259P	SIDM00789	Colorectal Carcinoma	GDSC	VFPYPD	LIG_APCC_ABBA_1	0.0833
p.L259P	ACH-000997	Colon/Colorectal Cancer	CCLE	VFPYPD	LIG_APCC_ABBA_1	0.0833
p.L259P	HCT-15	large_intestine	COSMIC	VFPYPD	LIG_APCC_ABBA_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IXS0	Protein FAM217A	LIG_APCC_ABBA_1	245:250	VFPYPD	APC,CDC20,FZR1	0.9937	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons