DegronMD - Q8IXS6(PALM2)

GO - Biological processes (BP): regulation of cell shape [GO:0008360]

GO - Molecular function (MF):

GO - Cellular component (CC): nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
VKVYDD	LIG_APCC_ABBA_1	APC,CDC20,FZR1	Paralemmin-2	169:174	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A169T	TCGA-A5-A0G2	UCEC	TCGA	VKVYDD	LIG_APCC_ABBA_1	169:174	Mutation altering degron motif	0.7139
p.A169V	TCGA-DA-A1IC	SKCM	TCGA	VKVYDD	LIG_APCC_ABBA_1	169:174	Mutation altering degron motif	0.6936
p.D173Y	DO229037	LICA	ICGC	VKVYDD	LIG_APCC_ABBA_1	169:174	Mutation altering degron motif	0.6214
p.D173G	DO50409	ESAD	ICGC	VKVYDD	LIG_APCC_ABBA_1	169:174	Mutation altering degron motif	0.6087
p.D173N	DO52686	MALY	ICGC	VKVYDD	LIG_APCC_ABBA_1	169:174	Mutation altering degron motif	0.5821
p.D177G	TCGA-FI-A2D5	UCEC	TCGA	VKVYDD	LIG_APCC_ABBA_1	169:174	Mutation substituting flanking lysine	0.3611
p.A168T	DO225328	BRCA	ICGC	VKVYDD	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.3056
p.V167M	DND-41	haematopoietic and lymphoid tissue	COSMIC	VKVYDD	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.2778
p.V167M	Daudi	haematopoietic and lymphoid tissue	COSMIC	VKVYDD	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.2778
p.K167R	DND-41	haematopoietic and lymphoid tissue	COSMIC	VKVYDD	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.2778
p.K167R	Daudi	haematopoietic and lymphoid tissue	COSMIC	VKVYDD	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.2778
p.A166V	DO233888	GACA	ICGC	VKVYDD	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.25
p.A166V	DO41752	UCEC	ICGC	VKVYDD	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.25
p.H165Q	DO227999	COCA	ICGC	VKVYDD	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.2222
p.H165Q	DO229346	LAML	ICGC	VKVYDD	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.2222
p.H165Q	DO229354	LAML	ICGC	VKVYDD	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.2222
p.H165N	DO51236	SKCM	ICGC	VKVYDD	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.2222
p.K165R	Daudi	haematopoietic and lymphoid tissue	COSMIC	VKVYDD	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.2222
p.K165R	DND-41	haematopoietic and lymphoid tissue	COSMIC	VKVYDD	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.2222
p.S164N	DO227549	COCA	ICGC	VKVYDD	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.1944

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Kaplan plot for PALM2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PALM2

UniProt ID: Q8IXS6

Entrez ID: 445815

Protein name: Paralemmin-2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PALM2 in