DegronMD - Q8IXS6(PALM2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A169T	TCGA-A5-A0G2	UCEC	TCGA	VKVYDD	LIG_APCC_ABBA_1	169:174	Mutation altering degron motif	0.7139
p.A169V	TCGA-DA-A1IC	SKCM	TCGA	VKVYDD	LIG_APCC_ABBA_1	169:174	Mutation altering degron motif	0.6936
p.D177G	TCGA-FI-A2D5	UCEC	TCGA	VKVYDD	LIG_APCC_ABBA_1	169:174	Mutation substituting flanking lysine	0.3611
p.A168T	DO225328	BRCA	ICGC	VKVYDD	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.3056
p.R183H	DO44086	COAD	ICGC	VKVYDD	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.0833
p.R183H	Daudi	haematopoietic and lymphoid tissue	COSMIC	VKVYDD	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.0833
p.S164N	DO227549	COCA	ICGC	VKVYDD	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.1944
p.H165Q	DO227999	COCA	ICGC	VKVYDD	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.2222
p.H165Q	DO229346	LAML	ICGC	VKVYDD	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.2222
p.H165Q	DO229354	LAML	ICGC	VKVYDD	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.2222
p.D173G	DO50409	ESAD	ICGC	VKVYDD	LIG_APCC_ABBA_1	169:174	Mutation altering degron motif	0.6087
p.A166V	DO233888	GACA	ICGC	VKVYDD	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.25
p.A166V	DO41752	UCEC	ICGC	VKVYDD	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.25
p.G160V	DO228925	LICA	ICGC	VKVYDD	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.0833
p.V164F	DO229018	LICA	ICGC	VKVYDD	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.1944
p.D173Y	DO229037	LICA	ICGC	VKVYDD	LIG_APCC_ABBA_1	169:174	Mutation altering degron motif	0.6214
p.R183L	DO23711	LUAD	ICGC	VKVYDD	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.0833
p.D173N	DO52686	MALY	ICGC	VKVYDD	LIG_APCC_ABBA_1	169:174	Mutation altering degron motif	0.5821
p.H165N	DO51236	SKCM	ICGC	VKVYDD	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.2222
p.R183C	DO42673	UCEC	ICGC	VKVYDD	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.0833
p.V167M	DND-41	haematopoietic and lymphoid tissue	COSMIC	VKVYDD	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.2778
p.V167M	Daudi	haematopoietic and lymphoid tissue	COSMIC	VKVYDD	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.2778
p.S162N	HCT-116	large intestine	COSMIC	VKVYDD	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.1389
p.K167R	DND-41	haematopoietic and lymphoid tissue	COSMIC	VKVYDD	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.2778
p.K167R	Daudi	haematopoietic and lymphoid tissue	COSMIC	VKVYDD	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.2778
p.R181H	Daudi	haematopoietic and lymphoid tissue	COSMIC	VKVYDD	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.1389
p.A164V	D-502MG	central nervous system	COSMIC	VKVYDD	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.1944
p.K165R	Daudi	haematopoietic and lymphoid tissue	COSMIC	VKVYDD	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.2222
p.K165R	DND-41	haematopoietic and lymphoid tissue	COSMIC	VKVYDD	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PALM2

UniProt ID: Q8IXS6

Entrez ID: 445815

Protein name: Paralemmin-2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PALM2 in