DegronMD

Uniprot ID: Q8IXS6

Source protein: Paralemmin-2

Source gene: PALM2

Class: LIG_APCC_ABBA_1

Location: 169:174

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9616

ASA_SCORE: 74.95

COIL: 0.548

CONS_SCORE: 0.9865

DSS_SCORE: 0.3421

HELIX: 0.0337

FCONS_SCORE: 1.1599

RIG_SCORE: 0.8119

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A169T	TCGA-A5-A0G2	UCEC	TCGA	VKVYDD	LIG_APCC_ABBA_1	0.7139
p.A169V	TCGA-DA-A1IC	SKCM	TCGA	VKVYDD	LIG_APCC_ABBA_1	0.6936
p.D177G	TCGA-FI-A2D5	UCEC	TCGA	VKVYDD	LIG_APCC_ABBA_1	0.3611
p.A168T	DO225328	BRCA	ICGC	VKVYDD	LIG_APCC_ABBA_1	0.3056
p.R183H	DO44086	COAD	ICGC	VKVYDD	LIG_APCC_ABBA_1	0.0833
p.R183H	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	VKVYDD	LIG_APCC_ABBA_1	0.0833
p.S164N	DO227549	COCA	ICGC	VKVYDD	LIG_APCC_ABBA_1	0.1944
p.H165Q	DO227999	COCA	ICGC	VKVYDD	LIG_APCC_ABBA_1	0.2222
p.H165Q	DO229346	LAML	ICGC	VKVYDD	LIG_APCC_ABBA_1	0.2222
p.H165Q	DO229354	LAML	ICGC	VKVYDD	LIG_APCC_ABBA_1	0.2222
p.D173G	DO50409	ESAD	ICGC	VKVYDD	LIG_APCC_ABBA_1	0.6087
p.A166V	DO233888	GACA	ICGC	VKVYDD	LIG_APCC_ABBA_1	0.25
p.A166V	DO41752	UCEC	ICGC	VKVYDD	LIG_APCC_ABBA_1	0.25
p.G160V	DO228925	LICA	ICGC	VKVYDD	LIG_APCC_ABBA_1	0.0833
p.V164F	DO229018	LICA	ICGC	VKVYDD	LIG_APCC_ABBA_1	0.1944
p.D173Y	DO229037	LICA	ICGC	VKVYDD	LIG_APCC_ABBA_1	0.6214
p.R183L	DO23711	LUAD	ICGC	VKVYDD	LIG_APCC_ABBA_1	0.0833
p.D173N	DO52686	MALY	ICGC	VKVYDD	LIG_APCC_ABBA_1	0.5821
p.H165N	DO51236	SKCM	ICGC	VKVYDD	LIG_APCC_ABBA_1	0.2222
p.R183C	DO42673	UCEC	ICGC	VKVYDD	LIG_APCC_ABBA_1	0.0833
p.V167M	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	VKVYDD	LIG_APCC_ABBA_1	0.2778
p.V167M	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	VKVYDD	LIG_APCC_ABBA_1	0.2778
p.S162N	HCT-116	large_intestine	COSMIC	VKVYDD	LIG_APCC_ABBA_1	0.1389
p.K167R	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	VKVYDD	LIG_APCC_ABBA_1	0.2778
p.K167R	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	VKVYDD	LIG_APCC_ABBA_1	0.2778
p.R181H	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	VKVYDD	LIG_APCC_ABBA_1	0.1389
p.A164V	D-502MG	central_nervous_system	COSMIC	VKVYDD	LIG_APCC_ABBA_1	0.1944
p.K165R	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	VKVYDD	LIG_APCC_ABBA_1	0.2222
p.K165R	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	VKVYDD	LIG_APCC_ABBA_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VKVYDD

Degron related mutations and impact score

Drug responses associated with PALM2 mutations

All proteins holding degron of VKVYDD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IXS6	Paralemmin-2	LIG_APCC_ABBA_1	169:174	VKVYDD	APC,CDC20,FZR1	0.9616	More...