DegronMD - Q8IY57(YAF2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V106E	TCGA-AB-2880	LAML	TCGA	TRPRLKNVD	DEG_APCC_DBOX_1	101:109	Mutation altering degron motif	0.7693
p.K103Q	TCGA-AN-A046	BRCA	TCGA	TRPRLKNVD	DEG_APCC_DBOX_1	101:109	Mutation altering degron motif	0.6944
p.K119N	TCGA-AX-A0J0	UCEC	TCGA	TRPRLKNVD	DEG_APCC_DBOX_1	101:109	Mutation rewiring degron network	0.0556
p.K103T	TCGA-B5-A0JY	UCEC	TCGA	TRPRLKNVD	DEG_APCC_DBOX_1	101:109	Mutation altering degron motif	0.7306
p.K119M	TCGA-P3-A6T4	HNSC	TCGA	TRPRLKNVD	DEG_APCC_DBOX_1	101:109	Mutation rewiring degron network	0.0556
p.A117D	DO49022	BRCA	ICGC	TRPRLKNVD	DEG_APCC_DBOX_1	101:109	Mutation rewiring degron network	0.1111
p.E93D	DO9876	COAD	ICGC	TRPRLKNVD	DEG_APCC_DBOX_1	101:109	Mutation rewiring degron network	0.1111
p.G103R	DO234467	ESAD	ICGC	TRPRLKNVD	DEG_APCC_DBOX_1	101:109	Mutation altering degron motif	0.7568
p.T104K	DO228948	LICA	ICGC	TRPRLKNVD	DEG_APCC_DBOX_1	101:109	Mutation altering degron motif	0.7306
p.T104K	DO229026	LICA	ICGC	TRPRLKNVD	DEG_APCC_DBOX_1	101:109	Mutation altering degron motif	0.7306
p.A92E	DO229022	LICA	ICGC	TRPRLKNVD	DEG_APCC_DBOX_1	101:109	Mutation rewiring degron network	0.0833
p.A119D	DO229009	LICA	ICGC	TRPRLKNVD	DEG_APCC_DBOX_1	101:109	Mutation rewiring degron network	0.0556
p.K109I	DO27508	LUSC	ICGC	TRPRLKNVD	DEG_APCC_DBOX_1	101:109	Mutation altering degron motif	0.7531
p.E108D	DO36881	READ	ICGC	TRPRLKNVD	DEG_APCC_DBOX_1	101:109	Mutation altering degron motif	0.6758
p.P103S	DO220056	SARC	ICGC	TRPRLKNVD	DEG_APCC_DBOX_1	101:109	Mutation altering degron motif	0.5641
p.R110W	DO229479	SKCA	ICGC	TRPRLKNVD	DEG_APCC_DBOX_1	101:109	Mutation rewiring degron network	0.3056
p.P113Q	DO37679	SKCM	ICGC	TRPRLKNVD	DEG_APCC_DBOX_1	101:109	Mutation rewiring degron network	0.2222
p.D105Y	DO41235	UCEC	ICGC	TRPRLKNVD	DEG_APCC_DBOX_1	101:109	Mutation altering degron motif	0.7325
p.G111E	DO43755	UCEC	ICGC	TRPRLKNVD	DEG_APCC_DBOX_1	101:109	Mutation rewiring degron network	0.2778
p.K110T	SIDM01588	Endometrial Carcinoma	GDSC	TRPRLKNVD	DEG_APCC_DBOX_1	101:109	Mutation rewiring degron network	0.3056
p.R110L	ACH-000941	Endometrial/Uterine Cancer	CCLE	TRPRLKNVD	DEG_APCC_DBOX_1	101:109	Mutation rewiring degron network	0.3056
p.R110L	ACH-000954	Endometrial/Uterine Cancer	CCLE	TRPRLKNVD	DEG_APCC_DBOX_1	101:109	Mutation rewiring degron network	0.3056
p.R110L	ACH-001517	Endometrial/Uterine Cancer	CCLE	TRPRLKNVD	DEG_APCC_DBOX_1	101:109	Mutation rewiring degron network	0.3056
p.R110L	HEC-1	endometrium	COSMIC	TRPRLKNVD	DEG_APCC_DBOX_1	101:109	Mutation rewiring degron network	0.3056
p.S112N	NUGC-3	stomach	COSMIC	TRPRLKNVD	DEG_APCC_DBOX_1	101:109	Mutation rewiring degron network	0.25

Kaplan plot for YAF2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

YAF2

UniProt ID: Q8IY57

Entrez ID: 10138

Protein name: YY1-associated factor 2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for YAF2 in