DegronMD

Uniprot ID: Q8IY57

Source protein: YY1-associated factor 2

Source gene: YAF2

Class: DEG_APCC_DBOX_1

Location: 101:109

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9781

ASA_SCORE: 98.5333

COIL: 0.7597

CONS_SCORE: 0.7547

DSS_SCORE: 0.6599

HELIX: 0.1596

FCONS_SCORE: 1.0979

RIG_SCORE: 0.6976

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V106E	TCGA-AB-2880	LAML	TCGA	TRPRLKNVD	DEG_APCC_DBOX_1	0.7693
p.K103Q	TCGA-AN-A046	BRCA	TCGA	TRPRLKNVD	DEG_APCC_DBOX_1	0.6944
p.K119N	TCGA-AX-A0J0	UCEC	TCGA	TRPRLKNVD	DEG_APCC_DBOX_1	0.0556
p.K103T	TCGA-B5-A0JY	UCEC	TCGA	TRPRLKNVD	DEG_APCC_DBOX_1	0.7306
p.K119M	TCGA-P3-A6T4	HNSC	TCGA	TRPRLKNVD	DEG_APCC_DBOX_1	0.0556
p.A117D	DO49022	BRCA	ICGC	TRPRLKNVD	DEG_APCC_DBOX_1	0.1111
p.E93D	DO9876	COAD	ICGC	TRPRLKNVD	DEG_APCC_DBOX_1	0.1111
p.G103R	DO234467	ESAD	ICGC	TRPRLKNVD	DEG_APCC_DBOX_1	0.7568
p.T104K	DO228948	LICA	ICGC	TRPRLKNVD	DEG_APCC_DBOX_1	0.7306
p.T104K	DO229026	LICA	ICGC	TRPRLKNVD	DEG_APCC_DBOX_1	0.7306
p.A92E	DO229022	LICA	ICGC	TRPRLKNVD	DEG_APCC_DBOX_1	0.0833
p.A119D	DO229009	LICA	ICGC	TRPRLKNVD	DEG_APCC_DBOX_1	0.0556
p.K109I	DO27508	LUSC	ICGC	TRPRLKNVD	DEG_APCC_DBOX_1	0.7531
p.E108D	DO36881	READ	ICGC	TRPRLKNVD	DEG_APCC_DBOX_1	0.6758
p.P103S	DO220056	SARC	ICGC	TRPRLKNVD	DEG_APCC_DBOX_1	0.5641
p.R110W	DO229479	SKCA	ICGC	TRPRLKNVD	DEG_APCC_DBOX_1	0.3056
p.P113Q	DO37679	SKCM	ICGC	TRPRLKNVD	DEG_APCC_DBOX_1	0.2222
p.D105Y	DO41235	UCEC	ICGC	TRPRLKNVD	DEG_APCC_DBOX_1	0.7325
p.G111E	DO43755	UCEC	ICGC	TRPRLKNVD	DEG_APCC_DBOX_1	0.2778
p.K110T	SIDM01588	Endometrial Carcinoma	GDSC	TRPRLKNVD	DEG_APCC_DBOX_1	0.3056
p.R110L	ACH-000941	Endometrial/Uterine Cancer	CCLE	TRPRLKNVD	DEG_APCC_DBOX_1	0.3056
p.R110L	ACH-000954	Endometrial/Uterine Cancer	CCLE	TRPRLKNVD	DEG_APCC_DBOX_1	0.3056
p.R110L	ACH-001517	Endometrial/Uterine Cancer	CCLE	TRPRLKNVD	DEG_APCC_DBOX_1	0.3056
p.R110L	HEC-1	endometrium	COSMIC	TRPRLKNVD	DEG_APCC_DBOX_1	0.3056
p.S112N	NUGC-3	stomach	COSMIC	TRPRLKNVD	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IY57	YY1-associated factor 2	DEG_APCC_DBOX_1	101:109	TRPRLKNVD	APC,CDC20,FZR1	0.9781	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TRPRLKNVD

Degron related mutations and impact score

Drug responses associated with YAF2 mutations

All proteins holding degron of TRPRLKNVD