DegronMD - Q8IY67(RAVER1)

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GO - Molecular function (MF): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P555A	TCGA-78-7150	LUAD	TCGA	TRPALPSVS	DEG_APCC_DBOX_1	556:564	Mutation rewiring degron network	0.3056
p.P555A	DO24411	LUAD	ICGC	TRPALPSVS	DEG_APCC_DBOX_1	556:564	Mutation rewiring degron network	0.3056
p.R553C	DO233088	GACA	ICGC	TRPALPSVS	DEG_APCC_DBOX_1	556:564	Mutation rewiring degron network	0.25
p.G550R	DO229029	LICA	ICGC	TRPALPSVS	DEG_APCC_DBOX_1	556:564	Mutation rewiring degron network	0.1667
p.R553H	DO228138	PBCA	ICGC	TRPALPSVS	DEG_APCC_DBOX_1	556:564	Mutation rewiring degron network	0.25
p.N562T	DO229133	THCA	ICGC	TRPALPSVS	DEG_APCC_DBOX_1	556:564	Mutation altering degron motif	0.7055
p.G558A	SIDM02015	Colorectal Carcinoma	GDSC	TRPALPSVS	DEG_APCC_DBOX_1	556:564	Mutation altering degron motif	0.754
p.A549T	SIDM01336	Glioblastoma	GDSC	TRPALPSVS	DEG_APCC_DBOX_1	556:564	Mutation rewiring degron network	0.1389
p.A549T	ACH-000368	Brain Cancer	CCLE	TRPALPSVS	DEG_APCC_DBOX_1	556:564	Mutation rewiring degron network	0.1389
p.R554H	ACH-002287	Colon/Colorectal Cancer	CCLE	TRPALPSVS	DEG_APCC_DBOX_1	556:564	Mutation rewiring degron network	0.2778
p.P564L	ACH-002309	Sarcoma	CCLE	TRPALPSVS	DEG_APCC_DBOX_1	556:564	Mutation altering degron motif	0.7582
p.P564S	ACH-002309	Sarcoma	CCLE	TRPALPSVS	DEG_APCC_DBOX_1	556:564	Mutation altering degron motif	0.6752
p.R557H	OVCAR-5	ovary	COSMIC	TRPALPSVS	DEG_APCC_DBOX_1	556:564	Mutation altering degron motif	0.8244
p.P554A	SK-MEL-24	skin	COSMIC	TRPALPSVS	DEG_APCC_DBOX_1	556:564	Mutation rewiring degron network	0.2778

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons