DegronMD

Uniprot ID: Q8IY67

Source protein: Ribonucleoprotein PTB-binding 1

Source gene: RAVER1

Class: DEG_APCC_DBOX_1

Location: 556:564

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9655

ASA_SCORE: 85.9

COIL: 0.9454

CONS_SCORE: 0.2532

DSS_SCORE: 0.587

HELIX: 0.0259

FCONS_SCORE: 1.0533

RIG_SCORE: 0.6556

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P555A	TCGA-78-7150	LUAD	TCGA	TRPALPSVS	DEG_APCC_DBOX_1	0.3056
p.P555A	DO24411	LUAD	ICGC	TRPALPSVS	DEG_APCC_DBOX_1	0.3056
p.R553C	DO233088	GACA	ICGC	TRPALPSVS	DEG_APCC_DBOX_1	0.25
p.G550R	DO229029	LICA	ICGC	TRPALPSVS	DEG_APCC_DBOX_1	0.1667
p.R553H	DO228138	PBCA	ICGC	TRPALPSVS	DEG_APCC_DBOX_1	0.25
p.N562T	DO229133	THCA	ICGC	TRPALPSVS	DEG_APCC_DBOX_1	0.7055
p.G558A	SIDM02015	Colorectal Carcinoma	GDSC	TRPALPSVS	DEG_APCC_DBOX_1	0.754
p.A549T	SIDM01336	Glioblastoma	GDSC	TRPALPSVS	DEG_APCC_DBOX_1	0.1389
p.A549T	ACH-000368	Brain Cancer	CCLE	TRPALPSVS	DEG_APCC_DBOX_1	0.1389
p.R554H	ACH-002287	Colon/Colorectal Cancer	CCLE	TRPALPSVS	DEG_APCC_DBOX_1	0.2778
p.P564L	ACH-002309	Sarcoma	CCLE	TRPALPSVS	DEG_APCC_DBOX_1	0.7582
p.P564S	ACH-002309	Sarcoma	CCLE	TRPALPSVS	DEG_APCC_DBOX_1	0.6752
p.R557H	OVCAR-5	ovary	COSMIC	TRPALPSVS	DEG_APCC_DBOX_1	0.8244
p.P554A	SK-MEL-24	skin	COSMIC	TRPALPSVS	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IY67	Ribonucleoprotein PTB-binding 1	DEG_APCC_DBOX_1	556:564	TRPALPSVS	APC,CDC20,FZR1	0.9655	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons