DegronMD - Q8IY85(EFCAB13)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y384C	TCGA-CK-5913	COAD	TCGA	IRKFLGGVG	DEG_APCC_DBOX_1	366:374	Mutation blocking phosphorylation signal	0.5
p.K361E	TCGA-D9-A6EA	SKCM	TCGA	IRKFLGGVG	DEG_APCC_DBOX_1	366:374	Mutation substituting flanking lysine	0.3056
p.K361Q	TCGA-D9-A6EC	SKCM	TCGA	IRKFLGGVG	DEG_APCC_DBOX_1	366:374	Mutation substituting flanking lysine	0.3056
p.F369C	TCGA-DK-A6AW	BLCA	TCGA	IRKFLGGVG	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.5996
p.F369C	TCGA-ND-A4WC	UCS	TCGA	IRKFLGGVG	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.5996
p.T356S	DO3852	BRCA	ICGC	IRKFLGGVG	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.0556
p.A357G	DO234371	ESAD	ICGC	IRKFLGGVG	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.0833
p.L371F	DO233792	GACA	ICGC	IRKFLGGVG	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.6981
p.L381R	DO233926	GACA	ICGC	IRKFLGGVG	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.1389
p.E366K	DO220909	MELA	ICGC	IRKFLGGVG	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.7022
p.L361M	DO37511	SKCM	ICGC	IRKFLGGVG	DEG_APCC_DBOX_1	366:374	Mutation substituting flanking lysine	0.3056
p.F364L	DO47769	STAD	ICGC	IRKFLGGVG	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.2778
p.F364V	DO43907	UCEC	ICGC	IRKFLGGVG	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.2778
p.N377K	SIDM01003	T-Lymphoblastic Leukemia	GDSC	IRKFLGGVG	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.25
p.N377K	KE-37	haematopoietic and lymphoid tissue	COSMIC	IRKFLGGVG	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.25
p.K368Q	SIDM00534	Colorectal Carcinoma	GDSC	IRKFLGGVG	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.5833
p.K368Q	ACH-000986	Colon/Colorectal Cancer	CCLE	IRKFLGGVG	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.5833
p.K368Q	HT-115	large intestine	COSMIC	IRKFLGGVG	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.5833
p.I358V	TUR	haematopoietic and lymphoid tissue	COSMIC	IRKFLGGVG	DEG_APCC_DBOX_1	366:374	Mutation substituting flanking lysine	0.2222
p.A357V	NB(TU)1-10	autonomic ganglia	COSMIC	IRKFLGGVG	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.0833
p.A357V	MMAC-SF	skin	COSMIC	IRKFLGGVG	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.0833
p.L361V	COLO-792	skin	COSMIC	IRKFLGGVG	DEG_APCC_DBOX_1	366:374	Mutation substituting flanking lysine	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EFCAB13

UniProt ID: Q8IY85

Entrez ID: 124989

Protein name: EF-hand calcium-binding domain-containing protein 13

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EFCAB13 in