DegronMD

Uniprot ID: Q8IY85

Source protein: EF-hand calcium-binding domain-containing protein 13

Source gene: EFCAB13

Class: DEG_APCC_DBOX_1

Location: 366:374

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6656

ASA_SCORE: 63.4778

COIL: 0.5543

CONS_SCORE: 0.5878

DSS_SCORE: 0.3986

HELIX: 0.1652

FCONS_SCORE: 0.9231

RIG_SCORE: 0.7617

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y384C	TCGA-CK-5913	COAD	TCGA	IRKFLGGVG	DEG_APCC_DBOX_1	0.5
p.K361E	TCGA-D9-A6EA	SKCM	TCGA	IRKFLGGVG	DEG_APCC_DBOX_1	0.3056
p.K361Q	TCGA-D9-A6EC	SKCM	TCGA	IRKFLGGVG	DEG_APCC_DBOX_1	0.3056
p.F369C	TCGA-DK-A6AW	BLCA	TCGA	IRKFLGGVG	DEG_APCC_DBOX_1	0.5996
p.F369C	TCGA-ND-A4WC	UCS	TCGA	IRKFLGGVG	DEG_APCC_DBOX_1	0.5996
p.T356S	DO3852	BRCA	ICGC	IRKFLGGVG	DEG_APCC_DBOX_1	0.0556
p.A357G	DO234371	ESAD	ICGC	IRKFLGGVG	DEG_APCC_DBOX_1	0.0833
p.L371F	DO233792	GACA	ICGC	IRKFLGGVG	DEG_APCC_DBOX_1	0.6981
p.L381R	DO233926	GACA	ICGC	IRKFLGGVG	DEG_APCC_DBOX_1	0.1389
p.E366K	DO220909	MELA	ICGC	IRKFLGGVG	DEG_APCC_DBOX_1	0.7022
p.L361M	DO37511	SKCM	ICGC	IRKFLGGVG	DEG_APCC_DBOX_1	0.3056
p.F364L	DO47769	STAD	ICGC	IRKFLGGVG	DEG_APCC_DBOX_1	0.2778
p.F364V	DO43907	UCEC	ICGC	IRKFLGGVG	DEG_APCC_DBOX_1	0.2778
p.N377K	SIDM01003	T-Lymphoblastic Leukemia	GDSC	IRKFLGGVG	DEG_APCC_DBOX_1	0.25
p.N377K	KE-37	haematopoietic_and_lymphoid_tissue	COSMIC	IRKFLGGVG	DEG_APCC_DBOX_1	0.25
p.K368Q	SIDM00534	Colorectal Carcinoma	GDSC	IRKFLGGVG	DEG_APCC_DBOX_1	0.5833
p.K368Q	ACH-000986	Colon/Colorectal Cancer	CCLE	IRKFLGGVG	DEG_APCC_DBOX_1	0.5833
p.K368Q	HT-115	large_intestine	COSMIC	IRKFLGGVG	DEG_APCC_DBOX_1	0.5833
p.I358V	TUR	haematopoietic_and_lymphoid_tissue	COSMIC	IRKFLGGVG	DEG_APCC_DBOX_1	0.2222
p.A357V	NB(TU)1-10	autonomic_ganglia	COSMIC	IRKFLGGVG	DEG_APCC_DBOX_1	0.0833
p.A357V	MMAC-SF	skin	COSMIC	IRKFLGGVG	DEG_APCC_DBOX_1	0.0833
p.L361V	COLO-792	skin	COSMIC	IRKFLGGVG	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IY85	EF-hand calcium-binding domain-containing protein 13	DEG_APCC_DBOX_1	366:374	IRKFLGGVG	APC,CDC20,FZR1	0.6656	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons