DegronMD - Q8IYA7(MKX)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R75Q	TCGA-2W-A8YY	CESC	TCGA	KRQALQDMA	DEG_APCC_DBOX_1	74:82	Mutation altering degron motif	0.7329
p.R75Q	DO223732	CESC	ICGC	KRQALQDMA	DEG_APCC_DBOX_1	74:82	Mutation altering degron motif	0.7329
p.R75W	TCGA-4W-AA9R	GBM	TCGA	KRQALQDMA	DEG_APCC_DBOX_1	74:82	Mutation altering degron motif	0.8634
p.R75W	TCGA-OD-A75X	SKCM	TCGA	KRQALQDMA	DEG_APCC_DBOX_1	74:82	Mutation altering degron motif	0.8634
p.R75W	DO219107	GBM	ICGC	KRQALQDMA	DEG_APCC_DBOX_1	74:82	Mutation altering degron motif	0.8634
p.R75W	DO48601	SKCM	ICGC	KRQALQDMA	DEG_APCC_DBOX_1	74:82	Mutation altering degron motif	0.8634
p.R75W	SIDM01296	Esophageal Carcinoma	GDSC	KRQALQDMA	DEG_APCC_DBOX_1	74:82	Mutation altering degron motif	0.8634
p.L78M	TCGA-A5-A0G2	UCEC	TCGA	KRQALQDMA	DEG_APCC_DBOX_1	74:82	Mutation altering degron motif	0.711
p.L78M	DO41235	UCEC	ICGC	KRQALQDMA	DEG_APCC_DBOX_1	74:82	Mutation altering degron motif	0.711
p.R65Q	TCGA-AJ-A3BH	UCEC	TCGA	KRQALQDMA	DEG_APCC_DBOX_1	74:82	Mutation rewiring degron network	0.0833
p.R65Q	DO41638	UCEC	ICGC	KRQALQDMA	DEG_APCC_DBOX_1	74:82	Mutation rewiring degron network	0.0833
p.Q76H	TCGA-AP-A051	UCEC	TCGA	KRQALQDMA	DEG_APCC_DBOX_1	74:82	Mutation altering degron motif	0.647
p.Q76H	DO42673	UCEC	ICGC	KRQALQDMA	DEG_APCC_DBOX_1	74:82	Mutation altering degron motif	0.647
p.L85P	TCGA-CG-5723	STAD	TCGA	KRQALQDMA	DEG_APCC_DBOX_1	74:82	Mutation rewiring degron network	0.25
p.L85P	DO38376	STAD	ICGC	KRQALQDMA	DEG_APCC_DBOX_1	74:82	Mutation rewiring degron network	0.25
p.G69R	TCGA-CK-6746	COAD	TCGA	KRQALQDMA	DEG_APCC_DBOX_1	74:82	Mutation rewiring degron network	0.1944
p.G69R	DO7938	COAD	ICGC	KRQALQDMA	DEG_APCC_DBOX_1	74:82	Mutation rewiring degron network	0.1944
p.G69R	SIDM00121	T-Lymphoblastic Leukemia	GDSC	KRQALQDMA	DEG_APCC_DBOX_1	74:82	Mutation rewiring degron network	0.1944
p.G69R	ACH-001738	Leukemia	CCLE	KRQALQDMA	DEG_APCC_DBOX_1	74:82	Mutation rewiring degron network	0.1944
p.G69R	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	KRQALQDMA	DEG_APCC_DBOX_1	74:82	Mutation rewiring degron network	0.1944
p.G69W	TCGA-D3-A2JO	SKCM	TCGA	KRQALQDMA	DEG_APCC_DBOX_1	74:82	Mutation rewiring degron network	0.1944
p.G69W	TCGA-FS-A1ZJ	SKCM	TCGA	KRQALQDMA	DEG_APCC_DBOX_1	74:82	Mutation rewiring degron network	0.1944
p.G69W	DO37956	SKCM	ICGC	KRQALQDMA	DEG_APCC_DBOX_1	74:82	Mutation rewiring degron network	0.1944
p.G69W	DO47619	SKCM	ICGC	KRQALQDMA	DEG_APCC_DBOX_1	74:82	Mutation rewiring degron network	0.1944
p.R83Q	TCGA-EO-A22R	UCEC	TCGA	KRQALQDMA	DEG_APCC_DBOX_1	74:82	Mutation rewiring degron network	0.3056
p.R83Q	DO42713	UCEC	ICGC	KRQALQDMA	DEG_APCC_DBOX_1	74:82	Mutation rewiring degron network	0.3056
p.A77T	TCGA-EO-A22U	UCEC	TCGA	KRQALQDMA	DEG_APCC_DBOX_1	74:82	Mutation altering degron motif	0.6028
p.A77T	DO43755	UCEC	ICGC	KRQALQDMA	DEG_APCC_DBOX_1	74:82	Mutation altering degron motif	0.6028
p.H73R	TCGA-EO-A22U	UCEC	TCGA	KRQALQDMA	DEG_APCC_DBOX_1	74:82	Mutation rewiring degron network	0.3056
p.H73R	DO43755	UCEC	ICGC	KRQALQDMA	DEG_APCC_DBOX_1	74:82	Mutation rewiring degron network	0.3056
p.A82V	DO233259	GACA	ICGC	KRQALQDMA	DEG_APCC_DBOX_1	74:82	Mutation altering degron motif	0.5825
p.A82V	DO233935	GACA	ICGC	KRQALQDMA	DEG_APCC_DBOX_1	74:82	Mutation altering degron motif	0.5825
p.H73Q	DO228974	LICA	ICGC	KRQALQDMA	DEG_APCC_DBOX_1	74:82	Mutation rewiring degron network	0.3056
p.R72S	DO45287	LIRI	ICGC	KRQALQDMA	DEG_APCC_DBOX_1	74:82	Mutation rewiring degron network	0.2778
p.A64S	DO52369	LUSC	ICGC	KRQALQDMA	DEG_APCC_DBOX_1	74:82	Mutation rewiring degron network	0.0556
p.H92Y	DO232648	PBCA	ICGC	KRQALQDMA	DEG_APCC_DBOX_1	74:82	Mutation rewiring degron network	0.0556
p.R65W	SIDM01609	Endometrial Carcinoma	GDSC	KRQALQDMA	DEG_APCC_DBOX_1	74:82	Mutation rewiring degron network	0.0833
p.R65W	ACH-000972	Endometrial/Uterine Cancer	CCLE	KRQALQDMA	DEG_APCC_DBOX_1	74:82	Mutation rewiring degron network	0.0833
p.K70E	ACH-000420	Liver Cancer	CCLE	KRQALQDMA	DEG_APCC_DBOX_1	74:82	Mutation substituting flanking lysine	0.3333
p.K70E	ACH-000668	Breast Cancer	CCLE	KRQALQDMA	DEG_APCC_DBOX_1	74:82	Mutation substituting flanking lysine	0.3333
p.K70E	ACH-001350	Thyroid Cancer	CCLE	KRQALQDMA	DEG_APCC_DBOX_1	74:82	Mutation substituting flanking lysine	0.3333
p.L78P	ACH-001182	Unknown	CCLE	KRQALQDMA	DEG_APCC_DBOX_1	74:82	Mutation altering degron motif	0.7582
p.L78P	ACH-002343	Non-Cancerous	CCLE	KRQALQDMA	DEG_APCC_DBOX_1	74:82	Mutation altering degron motif	0.7582
p.L78P	ACH-002361	Non-Cancerous	CCLE	KRQALQDMA	DEG_APCC_DBOX_1	74:82	Mutation altering degron motif	0.7582

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MKX

UniProt ID: Q8IYA7

Entrez ID: 283078

Protein name: Homeobox protein Mohawk

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MKX in