DegronMD

Uniprot ID: Q8IYA7

Source protein: Homeobox protein Mohawk

Source gene: MKX

Class: DEG_APCC_DBOX_1

Location: 74:82

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7933

ASA_SCORE: 66.3444

COIL: 0.3587

CONS_SCORE: 0.6708

DSS_SCORE: 0.5979

HELIX: 0.625

FCONS_SCORE: 1.0469

RIG_SCORE: 0.7544

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R75Q	TCGA-2W-A8YY	CESC	TCGA	KRQALQDMA	DEG_APCC_DBOX_1	0.7329
p.R75Q	DO223732	CESC	ICGC	KRQALQDMA	DEG_APCC_DBOX_1	0.7329
p.R75W	TCGA-4W-AA9R	GBM	TCGA	KRQALQDMA	DEG_APCC_DBOX_1	0.8634
p.R75W	TCGA-OD-A75X	SKCM	TCGA	KRQALQDMA	DEG_APCC_DBOX_1	0.8634
p.R75W	DO219107	GBM	ICGC	KRQALQDMA	DEG_APCC_DBOX_1	0.8634
p.R75W	DO48601	SKCM	ICGC	KRQALQDMA	DEG_APCC_DBOX_1	0.8634
p.R75W	SIDM01296	Esophageal Carcinoma	GDSC	KRQALQDMA	DEG_APCC_DBOX_1	0.8634
p.L78M	TCGA-A5-A0G2	UCEC	TCGA	KRQALQDMA	DEG_APCC_DBOX_1	0.711
p.L78M	DO41235	UCEC	ICGC	KRQALQDMA	DEG_APCC_DBOX_1	0.711
p.R65Q	TCGA-AJ-A3BH	UCEC	TCGA	KRQALQDMA	DEG_APCC_DBOX_1	0.0833
p.R65Q	DO41638	UCEC	ICGC	KRQALQDMA	DEG_APCC_DBOX_1	0.0833
p.Q76H	TCGA-AP-A051	UCEC	TCGA	KRQALQDMA	DEG_APCC_DBOX_1	0.647
p.Q76H	DO42673	UCEC	ICGC	KRQALQDMA	DEG_APCC_DBOX_1	0.647
p.L85P	TCGA-CG-5723	STAD	TCGA	KRQALQDMA	DEG_APCC_DBOX_1	0.25
p.L85P	DO38376	STAD	ICGC	KRQALQDMA	DEG_APCC_DBOX_1	0.25
p.G69R	TCGA-CK-6746	COAD	TCGA	KRQALQDMA	DEG_APCC_DBOX_1	0.1944
p.G69R	DO7938	COAD	ICGC	KRQALQDMA	DEG_APCC_DBOX_1	0.1944
p.G69R	SIDM00121	T-Lymphoblastic Leukemia	GDSC	KRQALQDMA	DEG_APCC_DBOX_1	0.1944
p.G69R	ACH-001738	Leukemia	CCLE	KRQALQDMA	DEG_APCC_DBOX_1	0.1944
p.G69R	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	KRQALQDMA	DEG_APCC_DBOX_1	0.1944
p.G69W	TCGA-D3-A2JO	SKCM	TCGA	KRQALQDMA	DEG_APCC_DBOX_1	0.1944
p.G69W	TCGA-FS-A1ZJ	SKCM	TCGA	KRQALQDMA	DEG_APCC_DBOX_1	0.1944
p.G69W	DO37956	SKCM	ICGC	KRQALQDMA	DEG_APCC_DBOX_1	0.1944
p.G69W	DO47619	SKCM	ICGC	KRQALQDMA	DEG_APCC_DBOX_1	0.1944
p.R83Q	TCGA-EO-A22R	UCEC	TCGA	KRQALQDMA	DEG_APCC_DBOX_1	0.3056
p.R83Q	DO42713	UCEC	ICGC	KRQALQDMA	DEG_APCC_DBOX_1	0.3056
p.A77T	TCGA-EO-A22U	UCEC	TCGA	KRQALQDMA	DEG_APCC_DBOX_1	0.6028
p.A77T	DO43755	UCEC	ICGC	KRQALQDMA	DEG_APCC_DBOX_1	0.6028
p.H73R	TCGA-EO-A22U	UCEC	TCGA	KRQALQDMA	DEG_APCC_DBOX_1	0.3056
p.H73R	DO43755	UCEC	ICGC	KRQALQDMA	DEG_APCC_DBOX_1	0.3056
p.A82V	DO233259	GACA	ICGC	KRQALQDMA	DEG_APCC_DBOX_1	0.5825
p.A82V	DO233935	GACA	ICGC	KRQALQDMA	DEG_APCC_DBOX_1	0.5825
p.H73Q	DO228974	LICA	ICGC	KRQALQDMA	DEG_APCC_DBOX_1	0.3056
p.R72S	DO45287	LIRI	ICGC	KRQALQDMA	DEG_APCC_DBOX_1	0.2778
p.A64S	DO52369	LUSC	ICGC	KRQALQDMA	DEG_APCC_DBOX_1	0.0556
p.H92Y	DO232648	PBCA	ICGC	KRQALQDMA	DEG_APCC_DBOX_1	0.0556
p.R65W	SIDM01609	Endometrial Carcinoma	GDSC	KRQALQDMA	DEG_APCC_DBOX_1	0.0833
p.R65W	ACH-000972	Endometrial/Uterine Cancer	CCLE	KRQALQDMA	DEG_APCC_DBOX_1	0.0833
p.K70E	ACH-000420	Liver Cancer	CCLE	KRQALQDMA	DEG_APCC_DBOX_1	0.3333
p.K70E	ACH-000668	Breast Cancer	CCLE	KRQALQDMA	DEG_APCC_DBOX_1	0.3333
p.K70E	ACH-001350	Thyroid Cancer	CCLE	KRQALQDMA	DEG_APCC_DBOX_1	0.3333
p.L78P	ACH-001182	Unknown	CCLE	KRQALQDMA	DEG_APCC_DBOX_1	0.7582
p.L78P	ACH-002343	Non-Cancerous	CCLE	KRQALQDMA	DEG_APCC_DBOX_1	0.7582
p.L78P	ACH-002361	Non-Cancerous	CCLE	KRQALQDMA	DEG_APCC_DBOX_1	0.7582

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KRQALQDMA

Degron related mutations and impact score

Drug responses associated with MKX mutations

All proteins holding degron of KRQALQDMA

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IYA7	Homeobox protein Mohawk	DEG_APCC_DBOX_1	74:82	KRQALQDMA	APC,CDC20,FZR1	0.7933	More...