DegronMD - Q8IYD9(LAS2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K166N	TCGA-B5-A11N	UCEC	TCGA	CRGRLGSLD	DEG_APCC_DBOX_1	155:163	Mutation substituting flanking lysine	0.3611
p.K166N	TCGA-B5-A3FC	UCEC	TCGA	CRGRLGSLD	DEG_APCC_DBOX_1	155:163	Mutation substituting flanking lysine	0.3611
p.K166N	DO41871	UCEC	ICGC	CRGRLGSLD	DEG_APCC_DBOX_1	155:163	Mutation substituting flanking lysine	0.3611
p.K166N	DO41458	UCEC	ICGC	CRGRLGSLD	DEG_APCC_DBOX_1	155:163	Mutation substituting flanking lysine	0.3611
p.H169R	TCGA-CG-4438	STAD	TCGA	CRGRLGSLD	DEG_APCC_DBOX_1	155:163	Mutation rewiring degron network	0.1667
p.H169R	DO38280	STAD	ICGC	CRGRLGSLD	DEG_APCC_DBOX_1	155:163	Mutation rewiring degron network	0.1667
p.K153N	TCGA-EO-A3B0	UCEC	TCGA	CRGRLGSLD	DEG_APCC_DBOX_1	155:163	Mutation rewiring degron network	0.2778
p.K153N	DO219773	UCEC	ICGC	CRGRLGSLD	DEG_APCC_DBOX_1	155:163	Mutation rewiring degron network	0.2778
p.R156C	TCGA-FI-A2D5	UCEC	TCGA	CRGRLGSLD	DEG_APCC_DBOX_1	155:163	Mutation altering degron motif	0.8301
p.R156C	TCGA-WE-A8K5	SKCM	TCGA	CRGRLGSLD	DEG_APCC_DBOX_1	155:163	Mutation altering degron motif	0.8301
p.R156C	DO233913	GACA	ICGC	CRGRLGSLD	DEG_APCC_DBOX_1	155:163	Mutation altering degron motif	0.8301
p.R156C	DO51282	SKCM	ICGC	CRGRLGSLD	DEG_APCC_DBOX_1	155:163	Mutation altering degron motif	0.8301
p.R156C	DO41331	UCEC	ICGC	CRGRLGSLD	DEG_APCC_DBOX_1	155:163	Mutation altering degron motif	0.8301
p.N167K	TCGA-HJ-7597	STAD	TCGA	CRGRLGSLD	DEG_APCC_DBOX_1	155:163	Mutation rewiring degron network	0.2222
p.N167K	DO38195	STAD	ICGC	CRGRLGSLD	DEG_APCC_DBOX_1	155:163	Mutation rewiring degron network	0.2222
p.T148M	DO227802	COCA	ICGC	CRGRLGSLD	DEG_APCC_DBOX_1	155:163	Mutation rewiring degron network	0.1389
p.R156S	DO222794	COCA	ICGC	CRGRLGSLD	DEG_APCC_DBOX_1	155:163	Mutation altering degron motif	0.7427
p.R147Q	DO233747	GACA	ICGC	CRGRLGSLD	DEG_APCC_DBOX_1	155:163	Mutation rewiring degron network	0.1111
p.R147W	DO38727	STAD	ICGC	CRGRLGSLD	DEG_APCC_DBOX_1	155:163	Mutation rewiring degron network	0.1111
p.S149N	SIDM00594	Acute Myeloid Leukemia	GDSC	CRGRLGSLD	DEG_APCC_DBOX_1	155:163	Mutation rewiring degron network	0.1667
p.S149N	SIDM00694	Other Solid Cancers	GDSC	CRGRLGSLD	DEG_APCC_DBOX_1	155:163	Mutation rewiring degron network	0.1667
p.S149R	SIDM00318	Kidney Carcinoma	GDSC	CRGRLGSLD	DEG_APCC_DBOX_1	155:163	Mutation rewiring degron network	0.1667
p.S149R	SIDM00965	Small Cell Lung Carcinoma	GDSC	CRGRLGSLD	DEG_APCC_DBOX_1	155:163	Mutation rewiring degron network	0.1667
p.K151E	SIDM00343	Glioblastoma	GDSC	CRGRLGSLD	DEG_APCC_DBOX_1	155:163	Mutation substituting flanking lysine	0.3333

Kaplan plot for LAS2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LAS2

UniProt ID: Q8IYD9

Entrez ID: 162681

Protein name: Lung adenoma susceptibility protein 2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LAS2 in