DegronMD

Uniprot ID: Q8IYD9

Source protein: Lung adenoma susceptibility protein 2

Source gene: LAS2

Class: DEG_APCC_DBOX_1

Location: 155:163

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.997

ASA_SCORE: 81.9222

COIL: 0.7971

CONS_SCORE: 0.5405

DSS_SCORE: 0.5256

HELIX: 0.1201

FCONS_SCORE: 1.1994

RIG_SCORE: 0.7234

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K166N	TCGA-B5-A11N	UCEC	TCGA	CRGRLGSLD	DEG_APCC_DBOX_1	0.3611
p.K166N	TCGA-B5-A3FC	UCEC	TCGA	CRGRLGSLD	DEG_APCC_DBOX_1	0.3611
p.K166N	DO41871	UCEC	ICGC	CRGRLGSLD	DEG_APCC_DBOX_1	0.3611
p.K166N	DO41458	UCEC	ICGC	CRGRLGSLD	DEG_APCC_DBOX_1	0.3611
p.H169R	TCGA-CG-4438	STAD	TCGA	CRGRLGSLD	DEG_APCC_DBOX_1	0.1667
p.H169R	DO38280	STAD	ICGC	CRGRLGSLD	DEG_APCC_DBOX_1	0.1667
p.K153N	TCGA-EO-A3B0	UCEC	TCGA	CRGRLGSLD	DEG_APCC_DBOX_1	0.2778
p.K153N	DO219773	UCEC	ICGC	CRGRLGSLD	DEG_APCC_DBOX_1	0.2778
p.R156C	TCGA-FI-A2D5	UCEC	TCGA	CRGRLGSLD	DEG_APCC_DBOX_1	0.8301
p.R156C	TCGA-WE-A8K5	SKCM	TCGA	CRGRLGSLD	DEG_APCC_DBOX_1	0.8301
p.R156C	DO233913	GACA	ICGC	CRGRLGSLD	DEG_APCC_DBOX_1	0.8301
p.R156C	DO51282	SKCM	ICGC	CRGRLGSLD	DEG_APCC_DBOX_1	0.8301
p.R156C	DO41331	UCEC	ICGC	CRGRLGSLD	DEG_APCC_DBOX_1	0.8301
p.N167K	TCGA-HJ-7597	STAD	TCGA	CRGRLGSLD	DEG_APCC_DBOX_1	0.2222
p.N167K	DO38195	STAD	ICGC	CRGRLGSLD	DEG_APCC_DBOX_1	0.2222
p.T148M	DO227802	COCA	ICGC	CRGRLGSLD	DEG_APCC_DBOX_1	0.1389
p.R156S	DO222794	COCA	ICGC	CRGRLGSLD	DEG_APCC_DBOX_1	0.7427
p.R147Q	DO233747	GACA	ICGC	CRGRLGSLD	DEG_APCC_DBOX_1	0.1111
p.R147W	DO38727	STAD	ICGC	CRGRLGSLD	DEG_APCC_DBOX_1	0.1111
p.S149N	SIDM00594	Acute Myeloid Leukemia	GDSC	CRGRLGSLD	DEG_APCC_DBOX_1	0.1667
p.S149N	SIDM00694	Other Solid Cancers	GDSC	CRGRLGSLD	DEG_APCC_DBOX_1	0.1667
p.S149R	SIDM00318	Kidney Carcinoma	GDSC	CRGRLGSLD	DEG_APCC_DBOX_1	0.1667
p.S149R	SIDM00965	Small Cell Lung Carcinoma	GDSC	CRGRLGSLD	DEG_APCC_DBOX_1	0.1667
p.K151E	SIDM00343	Glioblastoma	GDSC	CRGRLGSLD	DEG_APCC_DBOX_1	0.3333

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IYD9	Lung adenoma susceptibility protein 2	DEG_APCC_DBOX_1	155:163	CRGRLGSLD	APC,CDC20,FZR1	0.997	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons