DegronMD - Q8IYJ3(SYTL1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R467H	TCGA-2W-A8YY	CESC	TCGA	VRRSLSPVF	DEG_APCC_DBOX_1	465:473	Mutation altering degron motif	0.7133
p.R459H	TCGA-AG-3584	READ	TCGA	VRRSLSPVF	DEG_APCC_DBOX_1	465:473	Mutation rewiring degron network	0.1667
p.R455H	DO223732	CESC	ICGC	VRRSLSPVF	DEG_APCC_DBOX_1	465:473	Mutation rewiring degron network	0.0556
p.G469C	DO229008	LICA	ICGC	VRRSLSPVF	DEG_APCC_DBOX_1	465:473	Mutation altering degron motif	0.76
p.E481K	DO25444	LUAD	ICGC	VRRSLSPVF	DEG_APCC_DBOX_1	465:473	Mutation rewiring degron network	0.1111
p.S483F	DO37679	SKCM	ICGC	VRRSLSPVF	DEG_APCC_DBOX_1	465:473	Mutation rewiring degron network	0.0556
p.R476C	DO40978	UCEC	ICGC	VRRSLSPVF	DEG_APCC_DBOX_1	465:473	Mutation blocking phosphorylation signal	0.6944
p.R459C	SIDM00365	Small Cell Lung Carcinoma	GDSC	VRRSLSPVF	DEG_APCC_DBOX_1	465:473	Mutation rewiring degron network	0.1667
p.V478M	SIDM00951	T-Lymphoblastic Leukemia	GDSC	VRRSLSPVF	DEG_APCC_DBOX_1	465:473	Mutation rewiring degron network	0.1944
p.V478M	ACH-002222	Leukemia	CCLE	VRRSLSPVF	DEG_APCC_DBOX_1	465:473	Mutation rewiring degron network	0.1944
p.V478M	CTV-1	haematopoietic and lymphoid tissue	COSMIC	VRRSLSPVF	DEG_APCC_DBOX_1	465:473	Mutation rewiring degron network	0.1944
p.S470G	SIDM00980	Gastric Carcinoma	GDSC	VRRSLSPVF	DEG_APCC_DBOX_1	465:473	Mutation altering degron motif	0.6993
p.S470G	ACH-000948	Gastric Cancer	CCLE	VRRSLSPVF	DEG_APCC_DBOX_1	465:473	Mutation altering degron motif	0.6993
p.S470G	23132-87	stomach	COSMIC	VRRSLSPVF	DEG_APCC_DBOX_1	465:473	Mutation altering degron motif	0.6993
p.S458G	23132-87	stomach	COSMIC	VRRSLSPVF	DEG_APCC_DBOX_1	465:473	Mutation rewiring degron network	0.1389
p.P472S	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	VRRSLSPVF	DEG_APCC_DBOX_1	465:473	Mutation altering degron motif	0.6752
p.V466M	CTV-1	haematopoietic and lymphoid tissue	COSMIC	VRRSLSPVF	DEG_APCC_DBOX_1	465:473	Mutation altering degron motif	0.7208

Kaplan plot for SYTL1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SYTL1

UniProt ID: Q8IYJ3

Entrez ID: 84958

Protein name: Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SYTL1 in