DegronMD

Uniprot ID: Q8IYJ3

Source protein: Synaptotagmin-like protein 1

Source gene: SYTL1

Class: DEG_APCC_DBOX_1

Location: 465:473

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.582

ASA_SCORE: 77.7

COIL: 0.6938

CONS_SCORE: 0.6986

DSS_SCORE: 0.2616

HELIX: 0.0127

FCONS_SCORE: 0.9548

RIG_SCORE: 0.761

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R467H	TCGA-2W-A8YY	CESC	TCGA	VRRSLSPVF	DEG_APCC_DBOX_1	0.7133
p.R459H	TCGA-AG-3584	READ	TCGA	VRRSLSPVF	DEG_APCC_DBOX_1	0.1667
p.R455H	DO223732	CESC	ICGC	VRRSLSPVF	DEG_APCC_DBOX_1	0.0556
p.G469C	DO229008	LICA	ICGC	VRRSLSPVF	DEG_APCC_DBOX_1	0.76
p.E481K	DO25444	LUAD	ICGC	VRRSLSPVF	DEG_APCC_DBOX_1	0.1111
p.S483F	DO37679	SKCM	ICGC	VRRSLSPVF	DEG_APCC_DBOX_1	0.0556
p.R476C	DO40978	UCEC	ICGC	VRRSLSPVF	DEG_APCC_DBOX_1	0.6944
p.R459C	SIDM00365	Small Cell Lung Carcinoma	GDSC	VRRSLSPVF	DEG_APCC_DBOX_1	0.1667
p.V478M	SIDM00951	T-Lymphoblastic Leukemia	GDSC	VRRSLSPVF	DEG_APCC_DBOX_1	0.1944
p.V478M	ACH-002222	Leukemia	CCLE	VRRSLSPVF	DEG_APCC_DBOX_1	0.1944
p.V478M	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	VRRSLSPVF	DEG_APCC_DBOX_1	0.1944
p.S470G	SIDM00980	Gastric Carcinoma	GDSC	VRRSLSPVF	DEG_APCC_DBOX_1	0.6993
p.S470G	ACH-000948	Gastric Cancer	CCLE	VRRSLSPVF	DEG_APCC_DBOX_1	0.6993
p.S470G	23132-87	stomach	COSMIC	VRRSLSPVF	DEG_APCC_DBOX_1	0.6993
p.S458G	23132-87	stomach	COSMIC	VRRSLSPVF	DEG_APCC_DBOX_1	0.1389
p.P472S	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	VRRSLSPVF	DEG_APCC_DBOX_1	0.6752
p.V466M	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	VRRSLSPVF	DEG_APCC_DBOX_1	0.7208

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IYJ3	Synaptotagmin-like protein 1	DEG_APCC_DBOX_1	465:473	VRRSLSPVF	APC,CDC20,FZR1	0.582	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons