DegronMD - Q8IYK8(REM2)

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GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K42N	TCGA-AN-A046	BRCA	TCGA	PPGTPTPE	DEG_SCF_FBW7_2	28:35	Mutation substituting flanking lysine	0.25
p.K42N	DO1285	BRCA	ICGC	PPGTPTPE	DEG_SCF_FBW7_2	28:35	Mutation substituting flanking lysine	0.25
p.A36V	TCGA-EO-A22U	UCEC	TCGA	PPGTPTPE	DEG_SCF_FBW7_2	28:35	Mutation rewiring degron network	0.3056
p.A36V	DO43755	UCEC	ICGC	PPGTPTPE	DEG_SCF_FBW7_2	28:35	Mutation rewiring degron network	0.3056
p.S21C	TCGA-VS-A8Q8	CESC	TCGA	PPGTPTPE	DEG_SCF_FBW7_2	28:35	Mutation rewiring degron network	0.1389
p.S21C	DO51625	CESC	ICGC	PPGTPTPE	DEG_SCF_FBW7_2	28:35	Mutation rewiring degron network	0.1389
p.R24H	DO233693	GACA	ICGC	PPGTPTPE	DEG_SCF_FBW7_2	28:35	Mutation rewiring degron network	0.2222
p.C19Y	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PPGTPTPE	DEG_SCF_FBW7_2	28:35	Mutation rewiring degron network	0.0833
p.C19Y	ACH-000995	Leukemia	CCLE	PPGTPTPE	DEG_SCF_FBW7_2	28:35	Mutation rewiring degron network	0.0833
p.C19Y	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PPGTPTPE	DEG_SCF_FBW7_2	28:35	Mutation rewiring degron network	0.0833

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons