DegronMD

Uniprot ID: Q8IYK8

Source protein: GTP-binding protein REM 2

Source gene: REM2

Class: DEG_SCF_FBW7_2

Location: 28:35

E3 ligase: FBXW7

DEGRON score: 0.9816

ASA_SCORE: 82.925

COIL: 0.9179

CONS_SCORE: 0.3697

DSS_SCORE: 0.7711

HELIX: 0.059

FCONS_SCORE: 0.9908

RIG_SCORE: 0.5574

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K42N	TCGA-AN-A046	BRCA	TCGA	PPGTPTPE	DEG_SCF_FBW7_2	0.25
p.K42N	DO1285	BRCA	ICGC	PPGTPTPE	DEG_SCF_FBW7_2	0.25
p.A36V	TCGA-EO-A22U	UCEC	TCGA	PPGTPTPE	DEG_SCF_FBW7_2	0.3056
p.A36V	DO43755	UCEC	ICGC	PPGTPTPE	DEG_SCF_FBW7_2	0.3056
p.S21C	TCGA-VS-A8Q8	CESC	TCGA	PPGTPTPE	DEG_SCF_FBW7_2	0.1389
p.S21C	DO51625	CESC	ICGC	PPGTPTPE	DEG_SCF_FBW7_2	0.1389
p.R24H	DO233693	GACA	ICGC	PPGTPTPE	DEG_SCF_FBW7_2	0.2222
p.C19Y	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PPGTPTPE	DEG_SCF_FBW7_2	0.0833
p.C19Y	ACH-000995	Leukemia	CCLE	PPGTPTPE	DEG_SCF_FBW7_2	0.0833
p.C19Y	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PPGTPTPE	DEG_SCF_FBW7_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IYK8	GTP-binding protein REM 2	DEG_SCF_FBW7_2	28:35	PPGTPTPE	FBXW7	0.9816	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons