DegronMD - Q8IYN6(UBALD2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T64A	TCGA-VP-A87H	PRAD	TCGA	MMCTPSNT	DEG_SCF_FBW7_1	61:68	Mutation altering degron motif	0.7139
p.R78C	DO234374	ESAD	ICGC	MMCTPSNT	DEG_SCF_FBW7_1	61:68	Mutation rewiring degron network	0.0556
p.H57Q	DO52675	MALY	ICGC	MMCTPSNT	DEG_SCF_FBW7_1	61:68	Mutation rewiring degron network	0.2222
p.P66L	DO37409	SKCM	ICGC	MMCTPSNT	DEG_SCF_FBW7_1	61:68	Mutation altering degron motif	0.7582
p.S55G	DO229234	THCA	ICGC	MMCTPSNT	DEG_SCF_FBW7_1	61:68	Mutation rewiring degron network	0.1667
p.S59R	DO229085	THCA	ICGC	MMCTPSNT	DEG_SCF_FBW7_1	61:68	Mutation rewiring degron network	0.2778
p.S68P	DO229087	THCA	ICGC	MMCTPSNT	DEG_SCF_FBW7_1	61:68	Mutation altering degron motif	0.6752
p.S69P	DO229087	THCA	ICGC	MMCTPSNT	DEG_SCF_FBW7_1	61:68	Mutation rewiring degron network	0.3056
p.T71P	DO229087	THCA	ICGC	MMCTPSNT	DEG_SCF_FBW7_1	61:68	Mutation rewiring degron network	0.25
p.S55R	SIDM00871	Non-Cancerous	GDSC	MMCTPSNT	DEG_SCF_FBW7_1	61:68	Mutation rewiring degron network	0.1667
p.S55R	SIDM00872	Breast Carcinoma	GDSC	MMCTPSNT	DEG_SCF_FBW7_1	61:68	Mutation rewiring degron network	0.1667
p.S55R	ACH-000859	Breast Cancer	CCLE	MMCTPSNT	DEG_SCF_FBW7_1	61:68	Mutation rewiring degron network	0.1667
p.D77N	SIDM01088	Endometrial Carcinoma	GDSC	MMCTPSNT	DEG_SCF_FBW7_1	61:68	Mutation rewiring degron network	0.0833
p.D77N	ACH-000965	Endometrial/Uterine Cancer	CCLE	MMCTPSNT	DEG_SCF_FBW7_1	61:68	Mutation rewiring degron network	0.0833

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons