DegronMD

Uniprot ID: Q8IYN6

Source protein: UBA-like domain-containing protein 2

Source gene: UBALD2

Class: DEG_SCF_FBW7_1

Location: 61:68

E3 ligase: FBXW7

DEGRON score: 0.9818

ASA_SCORE: 68.75

COIL: 0.8844

CONS_SCORE: 0.7618

DSS_SCORE: 0.585

HELIX: 0.0531

FCONS_SCORE: 1.0657

RIG_SCORE: 0.6323

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T64A	TCGA-VP-A87H	PRAD	TCGA	MMCTPSNT	DEG_SCF_FBW7_1	0.7139
p.R78C	DO234374	ESAD	ICGC	MMCTPSNT	DEG_SCF_FBW7_1	0.0556
p.H57Q	DO52675	MALY	ICGC	MMCTPSNT	DEG_SCF_FBW7_1	0.2222
p.P66L	DO37409	SKCM	ICGC	MMCTPSNT	DEG_SCF_FBW7_1	0.7582
p.S55G	DO229234	THCA	ICGC	MMCTPSNT	DEG_SCF_FBW7_1	0.1667
p.S59R	DO229085	THCA	ICGC	MMCTPSNT	DEG_SCF_FBW7_1	0.2778
p.S68P	DO229087	THCA	ICGC	MMCTPSNT	DEG_SCF_FBW7_1	0.6752
p.S69P	DO229087	THCA	ICGC	MMCTPSNT	DEG_SCF_FBW7_1	0.3056
p.T71P	DO229087	THCA	ICGC	MMCTPSNT	DEG_SCF_FBW7_1	0.25
p.S55R	SIDM00871	Non-Cancerous	GDSC	MMCTPSNT	DEG_SCF_FBW7_1	0.1667
p.S55R	SIDM00872	Breast Carcinoma	GDSC	MMCTPSNT	DEG_SCF_FBW7_1	0.1667
p.S55R	ACH-000859	Breast Cancer	CCLE	MMCTPSNT	DEG_SCF_FBW7_1	0.1667
p.D77N	SIDM01088	Endometrial Carcinoma	GDSC	MMCTPSNT	DEG_SCF_FBW7_1	0.0833
p.D77N	ACH-000965	Endometrial/Uterine Cancer	CCLE	MMCTPSNT	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IYN6	UBA-like domain-containing protein 2	DEG_SCF_FBW7_1	61:68	MMCTPSNT	FBXW7	0.9818	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons