DegronMD - Q8IYQ7(THNSL1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R164H	TCGA-24-2033	OV	TCGA	IIVYLD	LIG_APCC_ABBA_1	150:155	Mutation rewiring degron network	0.0833
p.R164H	TCGA-A5-A0G2	UCEC	TCGA	IIVYLD	LIG_APCC_ABBA_1	150:155	Mutation rewiring degron network	0.0833
p.R164H	DO32143	OV	ICGC	IIVYLD	LIG_APCC_ABBA_1	150:155	Mutation rewiring degron network	0.0833
p.R164H	DO41235	UCEC	ICGC	IIVYLD	LIG_APCC_ABBA_1	150:155	Mutation rewiring degron network	0.0833
p.L145V	TCGA-78-8662	LUAD	TCGA	IIVYLD	LIG_APCC_ABBA_1	150:155	Mutation rewiring degron network	0.1944
p.L145V	DO45346	LUAD	ICGC	IIVYLD	LIG_APCC_ABBA_1	150:155	Mutation rewiring degron network	0.1944
p.R164C	TCGA-CF-A9FL	BLCA	TCGA	IIVYLD	LIG_APCC_ABBA_1	150:155	Mutation rewiring degron network	0.0833
p.R164C	DO223565	BLCA	ICGC	IIVYLD	LIG_APCC_ABBA_1	150:155	Mutation rewiring degron network	0.0833
p.W143L	DO229029	LICA	ICGC	IIVYLD	LIG_APCC_ABBA_1	150:155	Mutation rewiring degron network	0.1389
p.V156A	SIDM00251	Gastric Carcinoma	GDSC	IIVYLD	LIG_APCC_ABBA_1	150:155	Mutation rewiring degron network	0.3056
p.V156A	ACH-000949	Gastric Cancer	CCLE	IIVYLD	LIG_APCC_ABBA_1	150:155	Mutation rewiring degron network	0.3056
p.V156A	TGBC11TKB	stomach	COSMIC	IIVYLD	LIG_APCC_ABBA_1	150:155	Mutation rewiring degron network	0.3056
p.S141N	SIDM01618	B-Lymphoblastic Leukemia	GDSC	IIVYLD	LIG_APCC_ABBA_1	150:155	Mutation rewiring degron network	0.0833
p.S141N	ACH-000942	Leukemia	CCLE	IIVYLD	LIG_APCC_ABBA_1	150:155	Mutation rewiring degron network	0.0833

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons