DegronMD

Uniprot ID: Q8IYQ7

Source protein: Threonine synthase-like 1

Source gene: THNSL1

Class: LIG_APCC_ABBA_1

Location: 150:155

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5198

ASA_SCORE: 19.55

COIL: 0.1592

CONS_SCORE: 0.4852

DSS_SCORE: 0.0093

HELIX: 0.0118

FCONS_SCORE: 1.3172

RIG_SCORE: 0.9734

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R164H	TCGA-24-2033	OV	TCGA	IIVYLD	LIG_APCC_ABBA_1	0.0833
p.R164H	TCGA-A5-A0G2	UCEC	TCGA	IIVYLD	LIG_APCC_ABBA_1	0.0833
p.R164H	DO32143	OV	ICGC	IIVYLD	LIG_APCC_ABBA_1	0.0833
p.R164H	DO41235	UCEC	ICGC	IIVYLD	LIG_APCC_ABBA_1	0.0833
p.L145V	TCGA-78-8662	LUAD	TCGA	IIVYLD	LIG_APCC_ABBA_1	0.1944
p.L145V	DO45346	LUAD	ICGC	IIVYLD	LIG_APCC_ABBA_1	0.1944
p.R164C	TCGA-CF-A9FL	BLCA	TCGA	IIVYLD	LIG_APCC_ABBA_1	0.0833
p.R164C	DO223565	BLCA	ICGC	IIVYLD	LIG_APCC_ABBA_1	0.0833
p.W143L	DO229029	LICA	ICGC	IIVYLD	LIG_APCC_ABBA_1	0.1389
p.V156A	SIDM00251	Gastric Carcinoma	GDSC	IIVYLD	LIG_APCC_ABBA_1	0.3056
p.V156A	ACH-000949	Gastric Cancer	CCLE	IIVYLD	LIG_APCC_ABBA_1	0.3056
p.V156A	TGBC11TKB	stomach	COSMIC	IIVYLD	LIG_APCC_ABBA_1	0.3056
p.S141N	SIDM01618	B-Lymphoblastic Leukemia	GDSC	IIVYLD	LIG_APCC_ABBA_1	0.0833
p.S141N	ACH-000942	Leukemia	CCLE	IIVYLD	LIG_APCC_ABBA_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IYQ7	Threonine synthase-like 1	LIG_APCC_ABBA_1	150:155	IIVYLD	APC,CDC20,FZR1	0.5198	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons