DegronMD - Q8IYS4(DNAAF8)

FUNCTION: In cyliated cells, dynein axonemal particle-specific protein required for deployment of ODA to the axoneme. Interacts with outer dynein arm (ODA) subunits. {ECO:0000250|UniProtKB:A0A1L8EYB2}.

GO - Biological processes (BP): outer dynein arm assembly [GO:0036158]

GO - Molecular function (MF): dynein complex binding [GO:0070840]

GO - Cellular component (CC): dynein axonemal particle [GO:0120293]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P337L	TCGA-A3-3317	KIRC	TCGA	PADTPQDT	DEG_SCF_FBW7_1	333:340	Mutation altering degron motif	0.7582
p.D335N	TCGA-OR-A5LM	ACC	TCGA	PADTPQDT	DEG_SCF_FBW7_1	333:340	Mutation altering degron motif	0.5821
p.D335N	SIDM00149	Melanoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	333:340	Mutation altering degron motif	0.5821
p.R330W	SIDM00967	Ovarian Carcinoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	333:340	Mutation rewiring degron network	0.25
p.R330W	SIDM00656	Burkitt's Lymphoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	333:340	Mutation rewiring degron network	0.25
p.R330W	SIDM00087	Plasma Cell Myeloma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	333:340	Mutation rewiring degron network	0.25
p.R330W	SIDM00633	Breast Carcinoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	333:340	Mutation rewiring degron network	0.25
p.R330W	SIDM00690	Head and Neck Carcinoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	333:340	Mutation rewiring degron network	0.25
p.R330W	SIDM00210	Ovarian Carcinoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	333:340	Mutation rewiring degron network	0.25
p.R330W	SIDM00907	Burkitt's Lymphoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	333:340	Mutation rewiring degron network	0.25
p.R330W	SIDM00930	Osteosarcoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	333:340	Mutation rewiring degron network	0.25
p.R330W	SIDM00760	Small Cell Lung Carcinoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	333:340	Mutation rewiring degron network	0.25
p.R330W	SIDM00641	Burkitt's Lymphoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	333:340	Mutation rewiring degron network	0.25
p.R330L	SIDM00967	Ovarian Carcinoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	333:340	Mutation rewiring degron network	0.25
p.R330L	SIDM00656	Burkitt's Lymphoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	333:340	Mutation rewiring degron network	0.25
p.R330L	SIDM00087	Plasma Cell Myeloma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	333:340	Mutation rewiring degron network	0.25
p.R330L	SIDM00633	Breast Carcinoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	333:340	Mutation rewiring degron network	0.25
p.R330L	SIDM00690	Head and Neck Carcinoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	333:340	Mutation rewiring degron network	0.25
p.R330L	SIDM00210	Ovarian Carcinoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	333:340	Mutation rewiring degron network	0.25
p.R330L	SIDM00907	Burkitt's Lymphoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	333:340	Mutation rewiring degron network	0.25

Showing 1 to 20 of 29 entries

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Kaplan plot for DNAAF8 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DNAAF8

UniProt ID: Q8IYS4

Entrez ID: 146562

Protein name: Dynein axonemal assembly factor 8 (Dynein axonemal-associated protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DNAAF8 in