DegronMD

Uniprot ID: Q8IYS4

Source protein: Dynein axonemal assembly factor 8

Source gene: DNAAF8

Class: DEG_SCF_FBW7_1

Location: 333:340

E3 ligase: FBXW7

DEGRON score: 0.9918

ASA_SCORE: 82.5625

COIL: 0.8655

CONS_SCORE: 0.7276

DSS_SCORE: 0.5855

HELIX: 0.0985

FCONS_SCORE: 1.1568

RIG_SCORE: 0.6746

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P337L	TCGA-A3-3317	KIRC	TCGA	PADTPQDT	DEG_SCF_FBW7_1	0.7582
p.D335N	TCGA-OR-A5LM	ACC	TCGA	PADTPQDT	DEG_SCF_FBW7_1	0.5821
p.D335N	SIDM00149	Melanoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	0.5821
p.R330W	SIDM00967	Ovarian Carcinoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	0.25
p.R330W	SIDM00656	Burkitt's Lymphoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	0.25
p.R330W	SIDM00087	Plasma Cell Myeloma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	0.25
p.R330W	SIDM00633	Breast Carcinoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	0.25
p.R330W	SIDM00690	Head and Neck Carcinoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	0.25
p.R330W	SIDM00210	Ovarian Carcinoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	0.25
p.R330W	SIDM00907	Burkitt's Lymphoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	0.25
p.R330W	SIDM00930	Osteosarcoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	0.25
p.R330W	SIDM00760	Small Cell Lung Carcinoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	0.25
p.R330W	SIDM00641	Burkitt's Lymphoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	0.25
p.R330L	SIDM00967	Ovarian Carcinoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	0.25
p.R330L	SIDM00656	Burkitt's Lymphoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	0.25
p.R330L	SIDM00087	Plasma Cell Myeloma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	0.25
p.R330L	SIDM00633	Breast Carcinoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	0.25
p.R330L	SIDM00690	Head and Neck Carcinoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	0.25
p.R330L	SIDM00210	Ovarian Carcinoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	0.25
p.R330L	SIDM00907	Burkitt's Lymphoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	0.25
p.R330L	SIDM00930	Osteosarcoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	0.25
p.R330L	SIDM00760	Small Cell Lung Carcinoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	0.25
p.R330L	SIDM00641	Burkitt's Lymphoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	0.25
p.R330P	SIDM00380	Acute Myeloid Leukemia	GDSC	PADTPQDT	DEG_SCF_FBW7_1	0.25
p.Q328R	DO50804	LIRI	ICGC	PADTPQDT	DEG_SCF_FBW7_1	0.1944

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Drug responses associated with DNAAF8 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PADTPQDT

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IYS4	Dynein axonemal assembly factor 8	DEG_SCF_FBW7_1	333:340	PADTPQDT	FBXW7	0.9918	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PADTPQDT

Degron related mutations and impact score

Drug responses associated with DNAAF8 mutations

All proteins holding degron of PADTPQDT