DegronMD

Uniprot ID: Q8IYS4

Source protein: Dynein axonemal assembly factor 8

Source gene: DNAAF8

Class: DEG_SCF_FBW7_1

Location: 333:340

E3 ligase: FBXW7

DEGRON score: 0.9918

ASA_SCORE: 82.5625

COIL: 0.8655

CONS_SCORE: 0.7276

DSS_SCORE: 0.5855

HELIX: 0.0985

FCONS_SCORE: 1.1568

RIG_SCORE: 0.6746

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P337L	TCGA-A3-3317	KIRC	TCGA	PADTPQDT	DEG_SCF_FBW7_1	0.7582
p.D335N	TCGA-OR-A5LM	ACC	TCGA	PADTPQDT	DEG_SCF_FBW7_1	0.5821
p.D335N	SIDM00149	Melanoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	0.5821
p.A348V	DO227987	COCA	ICGC	PADTPQDT	DEG_SCF_FBW7_1	0.1111
p.C349F	DO228985	LICA	ICGC	PADTPQDT	DEG_SCF_FBW7_1	0.0833
p.Q328R	DO50804	LIRI	ICGC	PADTPQDT	DEG_SCF_FBW7_1	0.1944
p.Q328R	DO47873	STAD	ICGC	PADTPQDT	DEG_SCF_FBW7_1	0.1944
p.R330W	SIDM00967	Ovarian Carcinoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	0.25
p.R330W	SIDM00656	Burkitt's Lymphoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	0.25
p.R330W	SIDM00087	Plasma Cell Myeloma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	0.25
p.R330W	SIDM00633	Breast Carcinoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	0.25
p.R330W	SIDM00690	Head and Neck Carcinoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	0.25
p.R330W	SIDM00210	Ovarian Carcinoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	0.25
p.R330W	SIDM00907	Burkitt's Lymphoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	0.25
p.R330W	SIDM00930	Osteosarcoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	0.25
p.R330W	SIDM00760	Small Cell Lung Carcinoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	0.25
p.R330W	SIDM00641	Burkitt's Lymphoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	0.25
p.R330L	SIDM00967	Ovarian Carcinoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	0.25
p.R330L	SIDM00656	Burkitt's Lymphoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	0.25
p.R330L	SIDM00087	Plasma Cell Myeloma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	0.25
p.R330L	SIDM00633	Breast Carcinoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	0.25
p.R330L	SIDM00690	Head and Neck Carcinoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	0.25
p.R330L	SIDM00210	Ovarian Carcinoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	0.25
p.R330L	SIDM00907	Burkitt's Lymphoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	0.25
p.R330L	SIDM00930	Osteosarcoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	0.25
p.R330L	SIDM00760	Small Cell Lung Carcinoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	0.25
p.R330L	SIDM00641	Burkitt's Lymphoma	GDSC	PADTPQDT	DEG_SCF_FBW7_1	0.25
p.R330P	SIDM00380	Acute Myeloid Leukemia	GDSC	PADTPQDT	DEG_SCF_FBW7_1	0.25
p.D349N	ACH-000750	Skin Cancer	CCLE	PADTPQDT	DEG_SCF_FBW7_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PADTPQDT

Degron related mutations and impact score

Drug responses associated with DNAAF8 mutations

All proteins holding degron of PADTPQDT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IYS4	Dynein axonemal assembly factor 8	DEG_SCF_FBW7_1	333:340	PADTPQDT	FBXW7	0.9918	More...