DegronMD - Q8IYV9(IZUMO1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A243V	TCGA-23-1117	OV	TCGA	YRCELGSVN	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.2222
p.A243V	TCGA-CG-5728	STAD	TCGA	YRCELGSVN	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.2222
p.A243V	DO30830	OV	ICGC	YRCELGSVN	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.2222
p.A243V	DO38619	STAD	ICGC	YRCELGSVN	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.2222
p.H249L	TCGA-55-7994	LUAD	TCGA	YRCELGSVN	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.0556
p.H249L	DO45311	LUAD	ICGC	YRCELGSVN	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.0556
p.P242S	TCGA-A5-A0G1	UCEC	TCGA	YRCELGSVN	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.25
p.P242S	DO42472	UCEC	ICGC	YRCELGSVN	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.25
p.N247D	TCGA-F5-6814	READ	TCGA	YRCELGSVN	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.1111
p.N247D	DO36556	READ	ICGC	YRCELGSVN	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.1111
p.S240C	TCGA-XD-AAUH	PAAD	TCGA	YRCELGSVN	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.3056
p.S240C	DO51721	PAAD	ICGC	YRCELGSVN	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.3056
p.S237F	DO45299	LIRI	ICGC	YRCELGSVN	DEG_APCC_DBOX_1	231:239	Mutation altering degron motif	0.6871
p.E234K	SIDM00789	Colorectal Carcinoma	GDSC	YRCELGSVN	DEG_APCC_DBOX_1	231:239	Mutation altering degron motif	0.591
p.E234K	ACH-000997	Colon/Colorectal Cancer	CCLE	YRCELGSVN	DEG_APCC_DBOX_1	231:239	Mutation altering degron motif	0.591
p.E234K	ACH-001061	Colon/Colorectal Cancer	CCLE	YRCELGSVN	DEG_APCC_DBOX_1	231:239	Mutation altering degron motif	0.591
p.R232C	SIDM00451	T-Lymphoblastic Leukemia	GDSC	YRCELGSVN	DEG_APCC_DBOX_1	231:239	Mutation altering degron motif	0.8301
p.R232C	ACH-000937	Leukemia	CCLE	YRCELGSVN	DEG_APCC_DBOX_1	231:239	Mutation altering degron motif	0.8301
p.R232C	PF-382	haematopoietic and lymphoid tissue	COSMIC	YRCELGSVN	DEG_APCC_DBOX_1	231:239	Mutation altering degron motif	0.8301
p.H249Y	SIDM01059	Melanoma	GDSC	YRCELGSVN	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.0556
p.H249Y	ACH-000915	Skin Cancer	CCLE	YRCELGSVN	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.0556
p.H249Y	IPC-298	skin	COSMIC	YRCELGSVN	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.0556
p.V238A	SIDM01608	Endometrial Carcinoma	GDSC	YRCELGSVN	DEG_APCC_DBOX_1	231:239	Mutation altering degron motif	0.6936
p.V238A	ACH-000990	Endometrial/Uterine Cancer	CCLE	YRCELGSVN	DEG_APCC_DBOX_1	231:239	Mutation altering degron motif	0.6936
p.S241T	ACH-000783	Breast Cancer	CCLE	YRCELGSVN	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.2778

Kaplan plot for IZUMO1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IZUMO1

UniProt ID: Q8IYV9

Entrez ID: 284359

Protein name: Izumo sperm-egg fusion protein 1 (Oocyte binding/fusion factor) (OBF) (Sperm-specific protein izumo)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IZUMO1 in