DegronMD

Uniprot ID: Q8IYV9

Source protein: Izumo sperm-egg fusion protein 1

Source gene: IZUMO1

Class: DEG_APCC_DBOX_1

Location: 231:239

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5105

ASA_SCORE: 46.9

COIL: 0.3976

CONS_SCORE: 0.7192

DSS_SCORE: 0.375

HELIX: 0.0183

FCONS_SCORE: 0.9688

RIG_SCORE: 0.7379

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A243V	TCGA-23-1117	OV	TCGA	YRCELGSVN	DEG_APCC_DBOX_1	0.2222
p.A243V	TCGA-CG-5728	STAD	TCGA	YRCELGSVN	DEG_APCC_DBOX_1	0.2222
p.A243V	DO30830	OV	ICGC	YRCELGSVN	DEG_APCC_DBOX_1	0.2222
p.A243V	DO38619	STAD	ICGC	YRCELGSVN	DEG_APCC_DBOX_1	0.2222
p.H249L	TCGA-55-7994	LUAD	TCGA	YRCELGSVN	DEG_APCC_DBOX_1	0.0556
p.H249L	DO45311	LUAD	ICGC	YRCELGSVN	DEG_APCC_DBOX_1	0.0556
p.P242S	TCGA-A5-A0G1	UCEC	TCGA	YRCELGSVN	DEG_APCC_DBOX_1	0.25
p.P242S	DO42472	UCEC	ICGC	YRCELGSVN	DEG_APCC_DBOX_1	0.25
p.N247D	TCGA-F5-6814	READ	TCGA	YRCELGSVN	DEG_APCC_DBOX_1	0.1111
p.N247D	DO36556	READ	ICGC	YRCELGSVN	DEG_APCC_DBOX_1	0.1111
p.S240C	TCGA-XD-AAUH	PAAD	TCGA	YRCELGSVN	DEG_APCC_DBOX_1	0.3056
p.S240C	DO51721	PAAD	ICGC	YRCELGSVN	DEG_APCC_DBOX_1	0.3056
p.S237F	DO45299	LIRI	ICGC	YRCELGSVN	DEG_APCC_DBOX_1	0.6871
p.E234K	SIDM00789	Colorectal Carcinoma	GDSC	YRCELGSVN	DEG_APCC_DBOX_1	0.591
p.E234K	ACH-000997	Colon/Colorectal Cancer	CCLE	YRCELGSVN	DEG_APCC_DBOX_1	0.591
p.E234K	ACH-001061	Colon/Colorectal Cancer	CCLE	YRCELGSVN	DEG_APCC_DBOX_1	0.591
p.R232C	SIDM00451	T-Lymphoblastic Leukemia	GDSC	YRCELGSVN	DEG_APCC_DBOX_1	0.8301
p.R232C	ACH-000937	Leukemia	CCLE	YRCELGSVN	DEG_APCC_DBOX_1	0.8301
p.R232C	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	YRCELGSVN	DEG_APCC_DBOX_1	0.8301
p.H249Y	SIDM01059	Melanoma	GDSC	YRCELGSVN	DEG_APCC_DBOX_1	0.0556
p.H249Y	ACH-000915	Skin Cancer	CCLE	YRCELGSVN	DEG_APCC_DBOX_1	0.0556
p.H249Y	IPC-298	skin	COSMIC	YRCELGSVN	DEG_APCC_DBOX_1	0.0556
p.V238A	SIDM01608	Endometrial Carcinoma	GDSC	YRCELGSVN	DEG_APCC_DBOX_1	0.6936
p.V238A	ACH-000990	Endometrial/Uterine Cancer	CCLE	YRCELGSVN	DEG_APCC_DBOX_1	0.6936
p.S241T	ACH-000783	Breast Cancer	CCLE	YRCELGSVN	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IYV9	Izumo sperm-egg fusion protein 1	DEG_APCC_DBOX_1	231:239	YRCELGSVN	APC,CDC20,FZR1	0.5105	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: YRCELGSVN

Degron related mutations and impact score

Drug responses associated with IZUMO1 mutations

All proteins holding degron of YRCELGSVN