DegronMD - Q8IYW4(ENTHD1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L188I	TCGA-33-AASI	LUSC	TCGA	PTPDIS	DEG_SCF_FBW7_1	175:180	Mutation rewiring degron network	0.1111
p.L188I	DO219129	LUSC	ICGC	PTPDIS	DEG_SCF_FBW7_1	175:180	Mutation rewiring degron network	0.1111
p.K187E	TCGA-BT-A42F	BLCA	TCGA	PTPDIS	DEG_SCF_FBW7_1	175:180	Mutation substituting flanking lysine	0.25
p.K187E	DO49726	BLCA	ICGC	PTPDIS	DEG_SCF_FBW7_1	175:180	Mutation substituting flanking lysine	0.25
p.P177L	TCGA-DY-A1DF	READ	TCGA	PTPDIS	DEG_SCF_FBW7_1	175:180	Mutation altering degron motif	0.7582
p.P177L	DO233210	GACA	ICGC	PTPDIS	DEG_SCF_FBW7_1	175:180	Mutation altering degron motif	0.7582
p.P177L	DO233712	GACA	ICGC	PTPDIS	DEG_SCF_FBW7_1	175:180	Mutation altering degron motif	0.7582
p.P177L	DO37058	READ	ICGC	PTPDIS	DEG_SCF_FBW7_1	175:180	Mutation altering degron motif	0.7582
p.E183D	TCGA-E5-A4TZ	BLCA	TCGA	PTPDIS	DEG_SCF_FBW7_1	175:180	Mutation rewiring degron network	0.25
p.E183D	DO44055	BLCA	ICGC	PTPDIS	DEG_SCF_FBW7_1	175:180	Mutation rewiring degron network	0.25
p.D178V	SIDM00493	Other Solid Cancers	GDSC	PTPDIS	DEG_SCF_FBW7_1	175:180	Mutation altering degron motif	0.6674
p.D178V	ACH-001075	Lung Cancer	CCLE	PTPDIS	DEG_SCF_FBW7_1	175:180	Mutation altering degron motif	0.6674
p.D178V	NCI-H292	lung	COSMIC	PTPDIS	DEG_SCF_FBW7_1	175:180	Mutation altering degron motif	0.6674

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons