DegronMD

Uniprot ID: Q8IYW4

Source protein: ENTH domain-containing protein 1

Source gene: ENTHD1

Class: DEG_SCF_FBW7_1

Location: 175:180

E3 ligase: FBXW7

DEGRON score: 0.5901

ASA_SCORE: 68.5167

COIL: 0.891

CONS_SCORE: 0.5072

DSS_SCORE: 0.4383

HELIX: 0.09

FCONS_SCORE: 1.0344

RIG_SCORE: 0.7037

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L188I	TCGA-33-AASI	LUSC	TCGA	PTPDIS	DEG_SCF_FBW7_1	0.1111
p.L188I	DO219129	LUSC	ICGC	PTPDIS	DEG_SCF_FBW7_1	0.1111
p.K187E	TCGA-BT-A42F	BLCA	TCGA	PTPDIS	DEG_SCF_FBW7_1	0.25
p.K187E	DO49726	BLCA	ICGC	PTPDIS	DEG_SCF_FBW7_1	0.25
p.P177L	TCGA-DY-A1DF	READ	TCGA	PTPDIS	DEG_SCF_FBW7_1	0.7582
p.P177L	DO233210	GACA	ICGC	PTPDIS	DEG_SCF_FBW7_1	0.7582
p.P177L	DO233712	GACA	ICGC	PTPDIS	DEG_SCF_FBW7_1	0.7582
p.P177L	DO37058	READ	ICGC	PTPDIS	DEG_SCF_FBW7_1	0.7582
p.E183D	TCGA-E5-A4TZ	BLCA	TCGA	PTPDIS	DEG_SCF_FBW7_1	0.25
p.E183D	DO44055	BLCA	ICGC	PTPDIS	DEG_SCF_FBW7_1	0.25
p.D178V	SIDM00493	Other Solid Cancers	GDSC	PTPDIS	DEG_SCF_FBW7_1	0.6674
p.D178V	ACH-001075	Lung Cancer	CCLE	PTPDIS	DEG_SCF_FBW7_1	0.6674
p.D178V	NCI-H292	lung	COSMIC	PTPDIS	DEG_SCF_FBW7_1	0.6674

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IYW4	ENTH domain-containing protein 1	DEG_SCF_FBW7_1	175:180	PTPDIS	FBXW7	0.5901	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons