DegronMD - Q8IYW5(RNF168)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S215R	TCGA-02-2466	GBM	TCGA	PVTPKSE	DEG_SCF_FBW7_2	206:212	Mutation rewiring degron network	0.25
p.S215R	TCGA-04-1348	OV	TCGA	PVTPKSE	DEG_SCF_FBW7_2	206:212	Mutation rewiring degron network	0.25
p.S215R	DO13480	GBM	ICGC	PVTPKSE	DEG_SCF_FBW7_2	206:212	Mutation rewiring degron network	0.25
p.S215R	DO32546	OV	ICGC	PVTPKSE	DEG_SCF_FBW7_2	206:212	Mutation rewiring degron network	0.25
p.P209S	TCGA-A5-A0G1	UCEC	TCGA	PVTPKSE	DEG_SCF_FBW7_2	206:212	Mutation altering degron motif	0.6752
p.P209S	TCGA-BF-AAP4	SKCM	TCGA	PVTPKSE	DEG_SCF_FBW7_2	206:212	Mutation altering degron motif	0.6752
p.P209S	DO219468	SKCM	ICGC	PVTPKSE	DEG_SCF_FBW7_2	206:212	Mutation altering degron motif	0.6752
p.P209S	DO42472	UCEC	ICGC	PVTPKSE	DEG_SCF_FBW7_2	206:212	Mutation altering degron motif	0.6752
p.N200S	TCGA-BR-7851	STAD	TCGA	PVTPKSE	DEG_SCF_FBW7_2	206:212	Mutation rewiring degron network	0.1667
p.N200S	DO38711	STAD	ICGC	PVTPKSE	DEG_SCF_FBW7_2	206:212	Mutation rewiring degron network	0.1667
p.K218I	DO233218	GACA	ICGC	PVTPKSE	DEG_SCF_FBW7_2	206:212	Mutation blocking ubiquitination signal	0.6111
p.Q219K	DO228971	LICA	ICGC	PVTPKSE	DEG_SCF_FBW7_2	206:212	Mutation rewiring degron network	0.1389
p.P209T	DO229041	LICA	ICGC	PVTPKSE	DEG_SCF_FBW7_2	206:212	Mutation altering degron motif	0.7031
p.P209H	DO229009	LICA	ICGC	PVTPKSE	DEG_SCF_FBW7_2	206:212	Mutation altering degron motif	0.7694
p.P198S	DO222837	MELA	ICGC	PVTPKSE	DEG_SCF_FBW7_2	206:212	Mutation rewiring degron network	0.1111
p.S197A	DO222843	MELA	ICGC	PVTPKSE	DEG_SCF_FBW7_2	206:212	Mutation rewiring degron network	0.0833
p.R220S	SIDM01612	Endometrial Carcinoma	GDSC	PVTPKSE	DEG_SCF_FBW7_2	206:212	Mutation rewiring degron network	0.1111
p.R220S	ACH-000946	Endometrial/Uterine Cancer	CCLE	PVTPKSE	DEG_SCF_FBW7_2	206:212	Mutation rewiring degron network	0.1111

Kaplan plot for RNF168 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RNF168

UniProt ID: Q8IYW5

Entrez ID: 165918

Protein name: E3 ubiquitin-protein ligase RNF168 (hRNF168) (EC 2.3.2.27) (RING finger protein 168) (RING-type E3 ubiquitin transferase RNF168)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RNF168 in