DegronMD

Uniprot ID: Q8IYW5

Source protein: E3 ubiquitin-protein ligase RNF168

Source gene: RNF168

Class: DEG_SCF_FBW7_2

Location: 206:212

E3 ligase: FBXW7

DEGRON score: 0.5365

ASA_SCORE: 110.0286

COIL: 0.8987

CONS_SCORE: 0.4012

DSS_SCORE: 0.7231

HELIX: 0.0874

FCONS_SCORE: 0.963

RIG_SCORE: 0.6253

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S215R	TCGA-02-2466	GBM	TCGA	PVTPKSE	DEG_SCF_FBW7_2	0.25
p.S215R	TCGA-04-1348	OV	TCGA	PVTPKSE	DEG_SCF_FBW7_2	0.25
p.S215R	DO13480	GBM	ICGC	PVTPKSE	DEG_SCF_FBW7_2	0.25
p.S215R	DO32546	OV	ICGC	PVTPKSE	DEG_SCF_FBW7_2	0.25
p.P209S	TCGA-A5-A0G1	UCEC	TCGA	PVTPKSE	DEG_SCF_FBW7_2	0.6752
p.P209S	TCGA-BF-AAP4	SKCM	TCGA	PVTPKSE	DEG_SCF_FBW7_2	0.6752
p.P209S	DO219468	SKCM	ICGC	PVTPKSE	DEG_SCF_FBW7_2	0.6752
p.P209S	DO42472	UCEC	ICGC	PVTPKSE	DEG_SCF_FBW7_2	0.6752
p.N200S	TCGA-BR-7851	STAD	TCGA	PVTPKSE	DEG_SCF_FBW7_2	0.1667
p.N200S	DO38711	STAD	ICGC	PVTPKSE	DEG_SCF_FBW7_2	0.1667
p.K218I	DO233218	GACA	ICGC	PVTPKSE	DEG_SCF_FBW7_2	0.6111
p.Q219K	DO228971	LICA	ICGC	PVTPKSE	DEG_SCF_FBW7_2	0.1389
p.P209T	DO229041	LICA	ICGC	PVTPKSE	DEG_SCF_FBW7_2	0.7031
p.P209H	DO229009	LICA	ICGC	PVTPKSE	DEG_SCF_FBW7_2	0.7694
p.P198S	DO222837	MELA	ICGC	PVTPKSE	DEG_SCF_FBW7_2	0.1111
p.S197A	DO222843	MELA	ICGC	PVTPKSE	DEG_SCF_FBW7_2	0.0833
p.R220S	SIDM01612	Endometrial Carcinoma	GDSC	PVTPKSE	DEG_SCF_FBW7_2	0.1111
p.R220S	ACH-000946	Endometrial/Uterine Cancer	CCLE	PVTPKSE	DEG_SCF_FBW7_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IYW5	E3 ubiquitin-protein ligase RNF168	DEG_SCF_FBW7_2	206:212	PVTPKSE	FBXW7	0.5365	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons