DegronMD - Q8IZT8(HS3ST5)

HS3ST5

UniProt ID: Q8IZT8

Entrez ID: 222537

Protein name: Heparan sulfate glucosamine 3-O-sulfotransferase 5 (EC 2.8.2.23) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 5) (3-OST-5) (Heparan sulfate 3-O-sulfotransferase 5) (h3-OST-5)

External links: UniprotKB HGNC RefSeq COSMIC

Please click HERE for better display.

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K303R	TCGA-18-3409	LUSC	TCGA	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation substituting flanking lysine	0.2778
p.K303R	DO26444	LUSC	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation substituting flanking lysine	0.2778
p.R325H	TCGA-44-3398	LUAD	TCGA	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation rewiring degron network	0.0556
p.R325H	DO25030	LUAD	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation rewiring degron network	0.0556
p.R325H	SIDM01767	Squamous Cell Lung Carcinoma	GDSC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation rewiring degron network	0.0556
p.R325H	ACH-000553	Lung Cancer	CCLE	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation rewiring degron network	0.0556
p.R311S	TCGA-69-7980	LUAD	TCGA	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation altering degron motif	0.6316
p.R311S	DO23678	LUAD	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation altering degron motif	0.6316
p.R311S	SIDM00700	Non-Small Cell Lung Carcinoma	GDSC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation altering degron motif	0.6316
p.R311S	ACH-001363	Lung Cancer	CCLE	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation altering degron motif	0.6316
p.R311S	NCI-H2135	lung	COSMIC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation altering degron motif	0.6316
p.P318R	TCGA-77-8148	LUSC	TCGA	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation rewiring degron network	0.25
p.P318R	DO26458	LUSC	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation rewiring degron network	0.25
p.R311H	TCGA-86-8075	LUAD	TCGA	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation altering degron motif	0.7133
p.R311H	TCGA-AP-A1DV	UCEC	TCGA	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation altering degron motif	0.7133
p.R311H	DO224573	BRCA	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation altering degron motif	0.7133
p.R311H	DO1006	BRCA	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation altering degron motif	0.7133
p.R311H	DO25386	LUAD	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation altering degron motif	0.7133
p.R311H	DO43186	UCEC	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation altering degron motif	0.7133
p.R311H	SIDM01962	Colorectal Carcinoma	GDSC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation altering degron motif	0.7133
p.S308I	TCGA-86-8358	LUAD	TCGA	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation rewiring degron network	0.3056
p.S308I	DO25471	LUAD	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation rewiring degron network	0.3056
p.K303T	TCGA-AA-A010	COAD	TCGA	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation substituting flanking lysine	0.2778
p.R325C	TCGA-AP-A056	UCEC	TCGA	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation rewiring degron network	0.0556
p.R325C	TCGA-AP-A0LM	UCEC	TCGA	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation rewiring degron network	0.0556
p.R325C	TCGA-AP-A1DV	UCEC	TCGA	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation rewiring degron network	0.0556
p.R325C	TCGA-EI-6917	READ	TCGA	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation rewiring degron network	0.0556
p.R325C	TCGA-G3-AAV2	LIHC	TCGA	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation rewiring degron network	0.0556
p.R325C	TCGA-GM-A2DB	BRCA	TCGA	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation rewiring degron network	0.0556
p.R325C	TCGA-H7-7774	HNSC	TCGA	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation rewiring degron network	0.0556
p.R325C	TCGA-L5-A88V	ESCA	TCGA	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation rewiring degron network	0.0556
p.R325C	TCGA-MA-AA43	CESC	TCGA	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation rewiring degron network	0.0556
p.R325C	DO5179	BRCA	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation rewiring degron network	0.0556
p.R325C	DO219725	CESC	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation rewiring degron network	0.0556
p.R325C	DO14182	HNSC	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation rewiring degron network	0.0556
p.R325C	DO52296	LIHC	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation rewiring degron network	0.0556
p.R325C	DO36881	READ	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation rewiring degron network	0.0556
p.R325C	DO43306	UCEC	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation rewiring degron network	0.0556
p.R325C	DO43186	UCEC	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation rewiring degron network	0.0556
p.R325C	DO43971	UCEC	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation rewiring degron network	0.0556
p.R325C	SIDM00083	Glioblastoma	GDSC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation rewiring degron network	0.0556
p.R325C	ACH-000273	Brain Cancer	CCLE	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation rewiring degron network	0.0556
p.R325C	SF539	central nervous system	COSMIC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation rewiring degron network	0.0556
p.I312T	TCGA-B5-A11E	UCEC	TCGA	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation altering degron motif	0.7078
p.I312T	DO41644	UCEC	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation altering degron motif	0.7078
p.K309T	TCGA-B5-A3FA	UCEC	TCGA	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation altering degron motif	0.7306
p.K309T	DO52402	UCEC	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation altering degron motif	0.7306
p.P314L	TCGA-FR-A3YO	SKCM	TCGA	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation altering degron motif	0.6471
p.P314L	DO229177	LMS	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation altering degron motif	0.6471
p.P314L	DO37419	SKCM	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation altering degron motif	0.6471
p.T322N	DO228974	LICA	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation rewiring degron network	0.1389
p.D317E	DO229006	LICA	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation rewiring degron network	0.2778
p.P314S	DO229177	LMS	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation altering degron motif	0.5641
p.R311C	SIDM02059	Colorectal Carcinoma	GDSC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	309:315	Mutation altering degron motif	0.719

Kaplan plot for HS3ST5 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc